The proposed MBRS program is designed to address the professional growth needs of faculty to remain or become active in basic research and to contribute valid, original data which (as a long-term goal) can be integrated with the data of others, refined, and used by health-providers in prophylactic and/or therapeutic practices. The program intimately involves student participants who are provided the basis for graduate school in a biomedical science area. The projects are in biochemistry, gerontology, immunology, and psychology. In biochemistry, the project should provide data regarding gene organization and transcription in the eukaryote using a fungal system. In addition to information on discontinuous genes, it may provide unique information regarding the fungal genome that could be used in the management of fungal infections in mammals. The gerontological project is expected to provide insight into special nutritional needs of the aged population by defining the relationship between energy production-changes in mitochondria as a function of aging. The substrate preference of mitochondria in aged animal models will be explored in addition to the quantity and quality of enzymes in specific tissues and those changes that are detectable as the animal ages. The project in immunology proposes to determine the level of macrophage activation in animals immunized with the neoantigen generated on cell membranes by glutaraldehyde and to investigate the possibility that such immunizations could safely be used as a prophylactic or therapeutic tool in tumor management. The problem in psychology seeks to clarify the nature of intermodal organization in the sighted as compared with the visually impaired. Date obtained should result in the development of improved methods of educating the visually impaired. Such improvements should result in a better state of emotional health of such individuals. The conduct of the proposed research will increase the research capabilities of our institution by providing well-equipped and utilized laboratories in which the scientific curiosity of both faculty and students can be addressed.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Minority Biomedical Research Support - MBRS (S06)
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General Research Support Program Advisory Committee (GRS)
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Winston-Salem State University
Schools of Arts and Sciences
United States
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Heller, Morton A; Bracket, Deneen D; Salik, Shana S et al. (2003) Objects, raised lines, and the haptic horizontal-vertical illusion. Q J Exp Psychol A 56:891-907
Heller, M A; Calcaterra, J A; Green, S L et al. (1999) Perception of the horizontal and vertical in tangible displays: minimal gender differences. Perception 28:387-94
Heller, M A; Calcaterra, J A; Green, S L et al. (1999) Intersensory conflict between vision and touch: the response modality dominates when precise, attention-riveting judgments are required. Percept Psychophys 61:1384-98
Heller, M A; Calcaterra, J A; Burson, L L et al. (1997) The tactual horizontal-vertical illusion depends on radial motion of the entire arm. Percept Psychophys 59:1297-311
Heller, M A; Calcaterra, J A; Burson, L L et al. (1996) Tactual picture identification by blind and sighted people: effects of providing categorical information. Percept Psychophys 58:310-23
Heller, M A; Calcaterra, J A; Tyler, L A et al. (1996) Production and interpretation of perspective drawings by blind and sighted people. Perception 25:321-34
Heller, M A; Kennedy, J M; Joyner, T D (1995) Production and interpretation of pictures of houses by blind people. Perception 24:1049-58
Heller, M A (1993) Influence of visual guidance on braille recognition: low lighting also helps touch. Percept Psychophys 54:675-81
Heller, M A; Joyner, T D (1993) Mechanisms in the haptic horizontal-vertical illusion: evidence from sighted and blind subjects. Percept Psychophys 53:422-8
Heller, M A (1992) The effect of orientation on tactual braille recognition: optimal touching positions. Percept Psychophys 51:549-56

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