Abstract

Fungi produce a vast variety of bio-active secondary metabolites. One group of the metabolites consists of cyclic peptides and depsipeptides, which are often elaborated as families of closely related molecules. The biological activities of these molecules is as varied as their structures, though for convenience, we refer to them as mycotoxins. Because members of a family vary by minor structural modifications, they are ideal subjects for the study of the effect of side chain modification on peptide backbone conformation and, potentially, for the assignment of structure/function relationships. X-ray crystallography will be used in a systematic analysis of the structures and conformations of known peptide and depsipeptide mycotoxins, and as a primary analytical tool for the determination of the structures, absolute stereochemistry, and conformations of novel mycotoxins.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
2S06RR008102-17
Application #
3936828
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Puerto Rico Rio Piedras
Department
Type
DUNS #
City
San Juan
State
PR
Country
United States
Zip Code
00931

  Publications

Rodriguez, A D; Ramirez, C; Shi, Y P (2000) The cumbiasins, structurally novel diterpenes possessing intricate carbocyclic skeletons from the West Indian sea whip Pseudopterogorgia elisabethae (Bayer). J Org Chem 65:6682-7
Rodriguez, A D; Ramirez, C (2000) A marine diterpene with a novel tetracyclic framework from the West Indian gorgonian octocoral Pseudopterogorgia elisabethae. Org Lett 2:507-10
Rodriguez, A D; Soto, J J (1998) Pseudopterane and norcembrane diterpenoids from the Caribbean sea plume Pseudopterogorgia acerosa. J Nat Prod 61:401-4
Rodriguez, A D; Acosta, A L (1998) New cembranolides from the gorgonian Eunicea succinea. J Nat Prod 61:40-5
Richardson, P L; Rodriguez, A D; Boulanger, A et al. (1998) Methoxyamericanolide B. Acta Crystallogr C 54 ( Pt 1):66-8
Figueroa, I D; el Baraka, M; Quinones, E et al. (1998) A fluorescent temperature probe based on the association between the excited states of 4-(N,N-dimethylamino)benzonitrile and beta-cyclodextrin. Anal Chem 70:3974-7
Rodriguez, A D; Cobar, O M; Padilla, O L et al. (1997) Calyxamines A and B, novel piperidine alkaloids from the Caribbean sea sponge Calyx podatypa. J Nat Prod 60:1331-3
Cobar, O M; Rodriguez, A D; Padilla, O L (1997) A new steroidal glycoside from a Caribbean gorgonian, Eunicea sp.1. J Nat Prod 60:1186-8
Rodriguez, A D; Gonzalez, E; Huang, S D (1997) Euniciniatin. Acta Crystallogr C 53 ( Pt 3):311-3
Rodriguez, A; Acosta, A L (1997) New cembranoid diterpenes and a geranylgeraniol derivative from the common Caribbean sea whip Eunicea succinea. J Nat Prod 60:1134-8

Showing the most recent 10 out of 46 publications