Potential Anti-Tumor Transition Metal Complexes

Muir, Mariel M.

Abstract

Transition metal complexes of platinum(II), palladium(II), platinum(IV), gold(I), gold(III), rhodium(III), iridium(III), and lower oxidation states of rhodium and iridium will be prepared and evaluated for anti-tumor activity. A wide variety of ligands will be used, including ligands which also exhibit anti-tumor activity without complexation to the metal. X-ray structural studies will be carried out. The properties of the complexes in solution and their interactions with nucleobases and other biologically important molecules will be studied. Products of these interactions which can be crystallized will be subjected to X-ray structural analysis.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: Minority Biomedical Research Support - MBRS (S06)
• Project #: 2S06RR008102-17
• Application #: 3936819
• Support Year: 17
• Fiscal Year: 1988

Institution

• Name: University of Puerto Rico Rio Piedras
• City: San Juan
• State: PR
• Country: United States
• Zip Code: 00931

Publications

Rodriguez, A D; Ramirez, C; Shi, Y P (2000) The cumbiasins, structurally novel diterpenes possessing intricate carbocyclic skeletons from the West Indian sea whip Pseudopterogorgia elisabethae (Bayer). J Org Chem 65:6682-7

Rodriguez, A D; Ramirez, C (2000) A marine diterpene with a novel tetracyclic framework from the West Indian gorgonian octocoral Pseudopterogorgia elisabethae. Org Lett 2:507-10

Richardson, P L; Rodriguez, A D; Boulanger, A et al. (1998) Methoxyamericanolide B. Acta Crystallogr C 54 ( Pt 1):66-8

Figueroa, I D; el Baraka, M; Quinones, E et al. (1998) A fluorescent temperature probe based on the association between the excited states of 4-(N,N-dimethylamino)benzonitrile and beta-cyclodextrin. Anal Chem 70:3974-7

Rodriguez, A D; Soto, J J (1998) Pseudopterane and norcembrane diterpenoids from the Caribbean sea plume Pseudopterogorgia acerosa. J Nat Prod 61:401-4

Rodriguez, A D; Acosta, A L (1998) New cembranolides from the gorgonian Eunicea succinea. J Nat Prod 61:40-5

Rodriguez, A D; Cobar, O M; Padilla, O L et al. (1997) Calyxamines A and B, novel piperidine alkaloids from the Caribbean sea sponge Calyx podatypa. J Nat Prod 60:1331-3

Cobar, O M; Rodriguez, A D; Padilla, O L (1997) A new steroidal glycoside from a Caribbean gorgonian, Eunicea sp.1. J Nat Prod 60:1186-8

Rodriguez, A D; Gonzalez, E; Huang, S D (1997) Euniciniatin. Acta Crystallogr C 53 ( Pt 3):311-3

Rodriguez, A; Acosta, A L (1997) New cembranoid diterpenes and a geranylgeraniol derivative from the common Caribbean sea whip Eunicea succinea. J Nat Prod 60:1134-8