Abstract

The overall objective of the program is to establish a bonafide investigation in biochemical and pharmacological aspects of biomedical research. The proposed research program will involve studies from the subcellular to the organism level and in man, since any pharmacological response is a result of interrelated biochemical and pharmacological factors. The response may be a result of the action of a certain agent, and environmental contaminant, or response may be a result of the action of a certain agent, and environmental contaminant, or a result of interaction between an agent and a normal physiological process. Thus, it is necessary to monitor several interlocking aspects of the biochemical and physiological aspects involved.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06RR008111-16
Application #
3513983
Study Section
General Research Support Program Advisory Committee (GRS)
Project Start
1978-06-01
Project End
1989-02-28
Budget Start
1987-06-01
Budget End
1989-02-28
Support Year
16
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Florida Agricultural and Mechanical University
Department
Type
Schools of Pharmacy
DUNS #
City
Tallahassee
State
FL
Country
United States
Zip Code
32307

  Publications

Errahali, Younes J; Taka, Equar; Abonyo, Barack O et al. (2009) CCL26-targeted siRNA treatment of alveolar type II cells decreases expression of CCR3-binding chemokines and reduces eosinophil migration: implications in asthma therapy. J Interferon Cytokine Res 29:227-39
Taka, Equar; Errahali, Younes J; Abonyo, Barack O et al. (2008) Post-transcriptional silencing of CCR3 downregulates IL-4 stimulated release of eotaxin-3 (CCL26) and other CCR3 ligands in alveolar type II cells. Cytokine 44:342-51
You, Zhengqing; Lee, Henry Young (2006) New AZT conjugates as potent anti-HIV agents. Nucleosides Nucleotides Nucleic Acids 25:37-54
You, Zhengqing; Mian, A Moshin; Agarwal, Ram P et al. (2003) Synthesis, anti-HIV, and cytotoxic activity of new AZT conjugates of steroid acids. Nucleosides Nucleotides Nucleic Acids 22:2049-60
Badewa, A P; Heiman, A S (2003) Inhibition of CCL11, CCL24, and CCL26-induced degranulation in HL-60 eosinophilic cells by specific inhibitors of MEK1/MEK2, p38 MAP kinase, and PI 3-kinase. Immunopharmacol Immunotoxicol 25:145-57
Ko, Dong-Hoon; Heiman, Ann S; Hudson, Charles E et al. (2002) New steroidal antiinflammatory antedrugs: Methyl 3,20-dioxo-9 alpha-fluoro-11 beta,17 alpha,21-trihydroxy-1,4-pregnadiene-16 alpha-carboxylate and its 21-O-acyl derivatives. Steroids 67:211-9
Lee, Henry J; Cooperwood, John S; You, Zhengqing et al. (2002) Prodrug and antedrug: two diametrical approaches in designing safer drugs. Arch Pharm Res 25:111-36
Ko, D; Heiman, A S; Chen, M et al. (2000) New steroidal anti-inflammatory antedrugs: methyl 21-desoxy-21-chloro-11beta,17alpha-dihydroxy-3,20-dioxo-1, 4-pregnadiene-16alpha-carboxylate, methyl 21-desoxy-21-chloro-11beta-hydroxy-3,20-dioxo-1, 4-pregnadiene-16alpha-carboxylate, and their 9alpha-flu Steroids 65:210-8
Lee, H J; Ko, D H (1999) A novel approach to the discovery of non-systemic anti-inflammatory steroids;antedrug. Arch Pharm Res 22:279-87
Lee, H J; You, Z; Ko, D H et al. (1998) New steroidal antiinflammatory agents: prednisolone derivatives with an isoxazoline fusion at the 16- and 17-carbons and an alkyl carboxylate at the 16 alpha-position. Drugs Exp Clin Res 24:57-66

Showing the most recent 10 out of 34 publications