Abstract

This application requests funding for an Illumina NextSeq 500 system for deep sequencing services in The Genomics Research Program of the Rutgers New Jersey Medical School (NJMS). This application focuses on the needs of a group of NIH-funded biomedical researchers in diverse research fields, including infectious disease, cardiovascular research, neuroscience, oral biology, aging, cancer biology, and basic biomedical sciences. An array of projects will be carried out with the system, including genome sequencing, transcriptome analyses, and studies on protein-nucleic acid interactions. This system will play a critical role i advancing NIH- funded research projects involving deep sequencing at the Rutgers New Jersey Medical School and throughout the Rutgers Biomedical and Health Sciences Campuses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10OD018206-01A1
Application #
8826434
Study Section
Special Emphasis Panel (ZRG1-GGG-A (30))
Program Officer
Levy, Abraham
Project Start
2015-04-03
Project End
2016-04-02
Budget Start
2015-04-03
Budget End
2016-04-02
Support Year
1
Fiscal Year
2015
Total Cost
$227,250
Indirect Cost

  Institution

Name
Rutgers University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
078795851
City
Newark
State
NJ
Country
United States
Zip Code
07103

  Publications

Guo, Dong; Ma, Ji; Li, Tengfei et al. (2018) Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-?B pathway by targeting FOXO3. Exp Cell Res 369:34-42
Liu, Xiaochuan; Hoque, Mainul; Larochelle, Marc et al. (2017) Comparative analysis of alternative polyadenylation in S. cerevisiae and S. pombe. Genome Res 27:1685-1695
Elbarbary, Reyad A; Miyoshi, Keita; Myers, Jason R et al. (2017) Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition. Science 356:859-862
Zheng, Dinghai; Tian, Bin (2017) Polyadenylation Site-Based Analysis of Transcript Expression by 3'READS. Methods Mol Biol 1648:65-77
Chandramuki, Akepati; Khanna, Neelam; Shashkina, Elena et al. (2017) Genotypic characterisation of Mycobacterium tuberculosis isolates from tuberculous meningitis patients at a tertiary neurocare centre in Southern India. Indian J Med Microbiol 35:211-215
Liu, Xiaochuan; Freitas, Jaime; Zheng, Dinghai et al. (2017) Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster. RNA 23:1807-1816
Ogami, Koichi; Richard, Patricia; Chen, Yaqiong et al. (2017) An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression. Genes Dev 31:1257-1271
Vest, Katherine E; Phillips, Brittany L; Banerjee, Ayan et al. (2017) Novel mouse models of oculopharyngeal muscular dystrophy (OPMD) reveal early onset mitochondrial defects and suggest loss of PABPN1 may contribute to pathology. Hum Mol Genet 26:3235-3252
Fontes, Mariana M; Guvenek, Aysegul; Kawaguchi, Riki et al. (2017) Activity-Dependent Regulation of Alternative Cleavage and Polyadenylation During Hippocampal Long-Term Potentiation. Sci Rep 7:17377
Devany, Emral; Park, Ji Yeon; Murphy, Michael R et al. (2016) Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNA. Cell Discov 2:16013

Showing the most recent 10 out of 15 publications