Abstract

It is proposed to purchase an Evans & Sutherland PS 340 Color Graphics System to be installed in the computing center of the Department of Chemistry at Indiana University. This instrument will be used to display and manipulate molecular structures in three-dimensional representations using raster graphics for space filling models and vector graphics for skeletal models. The display of topological details of the molecular environment can be used by synthetic and mechanistic chemists to predict or rationalize chemical reactivity. Quantum mechanical and molecular mechanical, computer programs can be used in the associated computer to determine the relative energetics of various interactions and orientations visually displayed with the molecular graphics system. Applications will be in a variety of research programs including the structure and function of proteins and other biopolymers, drug design and the synthesis of natural products.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR002507-01
Application #
3519289
Study Section
(SSS)
Project Start
1984-12-01
Project End
1986-05-31
Budget Start
1984-12-01
Budget End
1986-05-31
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Indiana University Bloomington
Department
Type
Schools of Arts and Sciences
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47402

  Publications

Cain, L; Chatterjee, S; Collins, T J (1995) In vitro folliculogenesis of rat preantral follicles. Endocrinology 136:3369-77
Meryman, H T; Hornblower, M; Syring, R et al. (1994) Extending the storage of red cells at 4 degrees C. Transfus Sci 15:105-15
Schwaber, M K; Garraghty, P E; Kaas, J H (1993) Neuroplasticity of the adult primate auditory cortex following cochlear hearing loss. Am J Otol 14:252-8
Mincheff, M S; Meryman, H T; Kapoor, V et al. (1993) Blood transfusion and immunomodulation: a possible mechanism. Vox Sang 65:18-24
Gibson, G; Barrett, E (1992) The role of salivary function on oropharyngeal colonization. Spec Care Dentist 12:153-6
Farrell, P A; Caston, A L; Rodd, D (1991) Changes in insulin response to glucose after exercise training in partially pancreatectomized rats. J Appl Physiol 70:1563-8
Fahy, G M (1991) Short-term and long-term possibilities for interventive gerontology. Mt Sinai J Med 58:328-40
Madison, S; Walton, R (1990) Cervical root resorption following bleaching of endodontically treated teeth. J Endod 16:570-4
Benedict, R H; Harris, A E (1989) Remediation of attention deficits in chronic schizophrenic patients: a preliminary study. Br J Clin Psychol 28 ( Pt 2):187-8
Horowitz, L M; Rosenberg, S E; Ureno, G et al. (1989) Psychodynamic formulation, consensual response method, and interpersonal problems. J Consult Clin Psychol 57:599-606

Showing the most recent 10 out of 13 publications