This proposal is for the purchase of a complete single crystal X-ray diffractometer system for data collection and solution and refinement of molecular structures. The system is to consist of a diffractometer equipped with a low-temperature apparatus and a dedicated computer system for all crystallographic calculations. The instrument will be used by the X-Ray Crystallographic Laboratory to provide structure determinations for a wide range of health-related research projects that include: analysis of possible relationships between unsaturated polyolefins and hydrocarbon carcinogenesis; synthesis of cocarcinogens and diterpenes having powerful cytotoxic properties; evaluation of the possible antiviral role of polycondensed alicyclic molecules of high symmetry; synthesis of biologically active alkaloids and amino acid derived natural products; construction and analysis of mode of action of macrocyclic transition metal complexes in biomimetic chemistry; development of chelate dioxygen carriers for use in facilitated transport; biosynthesis of marine natural products and active microbial metabolites; stereochemistry of reactions at prochiral and proprochiral centers; biosynthesis of riboflavin and related compounds; multiple hydrogen bonding to nucleic acid bases; and much more.
| Black, S D; Sharma, P K; Gallucci, J C et al. (1992) Modulation of carcinogenicity in 1,2,3,4-tetrahydro-7,12- dimethylbenz[a]anthracene (THDMBA) by fluorine substitution: crystal structures of the 5- and 6-fluoro regioisomers. Carcinogenesis 13:1337-43 |
| Blackburn, A C; Gallucci, J C; Gerkin, R E (1991) Structure of tetraaquacopper(II) chlorate at 296 and 223 K. Acta Crystallogr B 47 ( Pt 4):474-9 |
| Fitzgerald, L J; Gallucci, J C; Gerkin, R E (1991) Structure of phenoxathiin (phenothioxin), C12H8OS, at 223 K. Acta Crystallogr C 47 ( Pt 2):381-5 |
| Blackburn, A C; Gallucci, J C; Gerkin, R E (1991) Structure of hexaaquacopper(II) bromate. Acta Crystallogr C 47 ( Pt 10):2019-23 |
| Blackburn, A C; Gallucci, J C; Gerkin, R E (1991) Structure of hexaaquanickel(II) bromate. Acta Crystallogr C 47 ( Pt 9):1786-9 |
| Blackburn, A C; Gallucci, J C; Gerkin, R E (1991) Structure of tetraaquacobalt(II) bromide dihydrate (cobalt bromide hexahydrate). Acta Crystallogr C 47 ( Pt 2):282-6 |
| Gallucci, J C; Gerkin, R E; Reppart, W J (1990) Structure of nickel(II) perbromate hexahydrate at 296 K. Acta Crystallogr C 46 ( Pt 9):1580-4 |
| Gallucci, J C; Gerkin, R E (1990) The structure of hexaaquanickel(II) chlorate. Acta Crystallogr C 46 ( Pt 3):350-4 |
| Blackburn, A C; Gallucci, J C; Gerkin, R E (1990) Structure of hexaaquacobalt(II) bromate. Acta Crystallogr B 46 ( Pt 6):712-6 |
| Gallucci, J C; Gerkin, R E (1989) Structure of copper(II) perchlorate hexahydrate. Acta Crystallogr C 45 ( Pt 9):1279-84 |
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