Abstract

The purpose of this application is to provide an automated cytogenetic core facilities to the investigators at U.T. M.D. Anderson Hospital and Tumor Institute. The field of cytogenetics has become an integral part of medicine not only in the area of prenatal diagnosis, but more recently in the area of cancer treatment and early diagnosis. With the development of Cytoscan, Genetiscan, and other automated systems one can eliminate the laborious steps of photography which include: (1) negative preparation, (2) printing, (3) cutting chromosomes, (4) karyotyping and, (5) subsequent printing for official reports. Acquisition of an automated karyotyping system will accelerate cytogenetic analysis of peripheral blood and solid tumor cultures enabling analysis of more cases in a much shorter time and with less expenditures. This machine can work 10-14 hrs a day continuously and can karyotype cells up to 200 chromosomes. The laser printer which is a part of the total package is able to print quality chromosome karyotypes with the push of a bottom for reproduction purposes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR004999-01
Application #
3520474
Study Section
(SSS)
Project Start
1988-09-30
Project End
1989-09-29
Budget Start
1988-09-30
Budget End
1989-09-29
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Type
Hospitals
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Greenberg, Solomon Maximo; Ferrara, Alfonso Massimiliano; Nicholas, Everton S et al. (2014) A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction. Thyroid 24:945-50
Ünlütürk, U?ur; Sriphrapradang, Chutintorn; Erdo?an, Murat Faik et al. (2013) Management of differentiated thyroid cancer in the presence of resistance to thyroid hormone and TSH-secreting adenomas: a report of four cases and review of the literature. J Clin Endocrinol Metab 98:2210-7
Ferrara, Alfonso Massimiliano; Cakir, Mehtap; Henry, Phillip H et al. (2013) Coexistence of THRB and TBG gene mutations in a Turkish family. J Clin Endocrinol Metab 98:E1148-51
Hermanns, Pia; Refetoff, Samuel; Sriphrapradang, Chutintorn et al. (2013) A clinically euthyroid child with a large goiter due to a thyroglobulin gene defect: clinical features and genetic studies. J Pediatr Endocrinol Metab 26:119-23
Dumitrescu, Alexandra M; Refetoff, Samuel (2013) The syndromes of reduced sensitivity to thyroid hormone. Biochim Biophys Acta 1830:3987-4003
Larsen, Cæcilie C; Dumitrescu, Alexandra; Guerra-Argüero, Laura M et al. (2013) Incidental identification of a thyroid hormone receptor beta (THRB) gene variant in a family with autoimmune thyroid disease. Thyroid 23:1638-43
Hermanns, Pia; Grasberger, Helmut; Cohen, Ronald et al. (2013) Two cases of thyroid dysgenesis caused by different novel PAX8 mutations in the DNA-binding region: in vitro studies reveal different pathogenic mechanisms. Thyroid 23:791-6
Verge, Charles F; Konrad, Daniel; Cohen, Michal et al. (2012) Diiodothyropropionic acid (DITPA) in the treatment of MCT8 deficiency. J Clin Endocrinol Metab 97:4515-23
Ferrara, Alfonso Massimiliano; Onigata, Kazumichi; Ercan, Oya et al. (2012) Homozygous thyroid hormone receptor ýý-gene mutations in resistance to thyroid hormone: three new cases and review of the literature. J Clin Endocrinol Metab 97:1328-36
Sriphrapradang, Chutintorn; German, Alina; Dumitrescu, Alexandra M et al. (2012) Consecutive mutational events in a TSHR allele of Arab families with resistance to thyroid stimulating hormone. Thyroid 22:252-7

Showing the most recent 10 out of 76 publications