This application proposes to replace outdated DNA sequencing technology (discontinued by manufacturer on 6/30/06) with a state of the art machine. The broad objectives of this proposal are to enrich ongoing psychiatric and behavioral research at Brown University and collaborating institutions through the integration of molecular genetics with the intensive phenotypic and environmental data currently being collected.
The specific aim of the is proposal is to replace the no-longer supported Applied Biosystems 377 DNA Sequencer with a state-of-the-art Applied Biosystems 3130xl Genetic Analyzer. Obtaining a new genetic analyzer would allow uninterrupted progress in identifying genetic moderators of drug's effects (e.g., McGeary et al 2004), defining genetic contributions to gene by environment interactions (e.g., Gibb et al, 2006) and defining psychiatric subtypes (e.g., McGeary et al., 2006). Current research projects that would benefit from this acquisition include numerous trials of medications for alcohol and nicotine dependence with the goal of improving pharmacological treatments through the identification of genetic variation that predicts positive response (good treatment outcome) and negative response (side effects). There are 19 research proposals currently under review that would benefit from access to this equipment. These projects span multiple methodologies and include neuroimaging assessment studies, human lab challenge studies of multiple drugs of abuse, assessments of obesity, depression and anxiety disorders and investigations of genetic influences on human sleep. ? ? ?
|Huang, Huiyan; Zhu, Yong; Eliot, Melissa N et al. (2017) Combining Human Epigenetics and Sleep Studies in Caenorhabditis elegans: A Cross-Species Approach for Finding Conserved Genes Regulating Sleep. Sleep 40:|
|Barker, David H; Nugent, Nicole R; Delgado, Jeanne R et al. (2017) A genetic marker of risk in HIV-infected individuals with a history of hazardous drinking. AIDS Care 29:1186-1191|
|Feurer, Cope; McGeary, John E; Knopik, Valerie S et al. (2017) HPA axis multilocus genetic profile score moderates the impact of interpersonal stress on prospective increases in depressive symptoms for offspring of depressed mothers. J Abnorm Psychol 126:1017-1028|
|Stuart, Gregory L; McGeary, John; Shorey, Ryan C et al. (2016) Genetics moderate alcohol and intimate partner violence treatment outcomes in a randomized controlled trial of hazardous drinking men in batterer intervention programs: A preliminary investigation. J Consult Clin Psychol 84:592-8|
|Nolden, Alissa A; McGeary, John E; Hayes, John E (2016) Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes. Physiol Behav 156:117-27|
|Owens, Max; Harrison, Ashley J; Burkhouse, Katie L et al. (2016) Eye tracking indices of attentional bias in children of depressed mothers: Polygenic influences help to clarify previous mixed findings. Dev Psychopathol 28:385-97|
|Kudinova, Anastacia Y; Deak, Terrence; Hueston, Cara M et al. (2016) Cross-species evidence for the role of interleukin-33 in depression risk. J Abnorm Psychol 125:482-94|
|Pearson, Rahel; McGeary, John; Maddox, W Todd et al. (2016) Serotonin promoter polymorphism (5-HTTLPR) predicts biased attention for emotion stimuli: Preliminary evidence of moderation by the social environment. Clin Psychol Sci 4:122-128|
|Lechner, William V; Knopik, Valerie S; McGeary, John E et al. (2016) Influence of the A118G Polymorphism of the OPRM1 Gene and Exon 3 VNTR Polymorphism of the DRD4 Gene on Cigarette Craving After Alcohol Administration. Nicotine Tob Res 18:632-6|
|Woody, Mary L; Kudinova, Anastacia Y; McGeary, John E et al. (2016) Influence of maternal depression on children's brooding rumination: Moderation by CRHR1 TAT haplotype. Cogn Emot 30:302-14|
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