This application seeks partial support for a magnetic resonance imaging (MRI) and spectroscopy (MRS) instrument equipped with an ultrahigh magnetic field for in vivo studies of animal models. The proposed animal MRI/MRS instrument will be based on a horizontal 16.4 T magnet having a clear bore diameter of 26 cm, which will be the first of its kind in the nation. It will be located in the Center for Magnetic Resonance Research (CMRR), to take advantage of the high field MR expertise and infrastructure already in place and supported by the NIH. This ultrahigh field MR system will support and enhance research being conducted within a Biotechnology Research Resource grant (P41 RR008079), a Neuroscience Core Center grant (P30 NS057091), and numerous projects funded by R01 and other grants. Among its many new capabilities, this unique 16.4T MR system will provide increased spatial resolution (e.g., for imaging Alzheimer's plaques in mice), increased spatial resolution and specificity in fMRI (e.g., for mapping functional structures in the brain), and increased sensitivity and biochemical information in MRS (e.g., for understanding the coupling between brain function and energy metabolism). ?

Public Health Relevance

Quantitative imaging is essential to understanding all types of brain diseases. In vivo MRS and MRI has contributed significantly to the current knowledge of normal and diseased brain, but the achievable sensitivity and resolution (spatial and spectral) are limited by the strength of the magnetic field. The proposed MRI/MRS instrument will offer a substantially increased magnetic field (16.4 T) over previous in vivo MR systems, and thus, will yield new structural, functional, and biochemical information in studies of normal brain and disease models. This knowledge, together with the advanced MRI and MRS techniques to be developed, will offer valuable tools for preclinical trials of novel therapeutic agents, and ultimately, for early disease detection and guiding treatments in the clinic. ? ? ?

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biomedical Research Support Shared Instrumentation Grants (S10)
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Special Emphasis Panel (ZRG1-SBIB-N (30))
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Tingle, Marjorie
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University of Minnesota Twin Cities
Schools of Medicine
United States
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Lu, Ming; Zhu, Xiao-Hong; Zhang, Yi et al. (2017) Quantitative assessment of brain glucose metabolic rates using in vivo deuterium magnetic resonance spectroscopy. J Cereb Blood Flow Metab 37:3518-3530
Kirberger, Steven E; Maltseva, Sofia D; Manulik, Joseph C et al. (2017) Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High-Signal 19 F MRI Agents. Angew Chem Int Ed Engl 56:6440-6444
Lee, Amani L; Gee, Clifford T; Weegman, Bradley P et al. (2017) Oxygen Sensing with Perfluorocarbon-Loaded Ultraporous Mesostructured Silica Nanoparticles. ACS Nano 11:5623-5632
Einstein, Samuel A; Weegman, Bradley P; Kitzmann, Jennifer P et al. (2017) Noninvasive assessment of tissue-engineered graft viability by oxygen-17 magnetic resonance spectroscopy. Biotechnol Bioeng 114:1118-1121
Einstein, Samuel A; Weegman, Bradley P; Firpo, Meri T et al. (2016) Development and Validation of Noninvasive Magnetic Resonance Relaxometry for the In Vivo Assessment of Tissue-Engineered Graft Oxygenation. Tissue Eng Part C Methods 22:1009-1017
Lou, Song; Lepak, Victoria C; Eberly, Lynn E et al. (2016) Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress. Hum Mol Genet 25:2813-2826
Lu, Ming; Zhu, Xiao-Hong; Zhang, Yi et al. (2014) Intracellular redox state revealed by in vivo (31) P MRS measurement of NAD(+) and NADH contents in brains. Magn Reson Med 71:1959-72
Lu, Ming; Chen, Wei; Zhu, Xiao-Hong (2014) Field dependence study of in vivo brain (31) P MRS up to 16.4?T. NMR Biomed 27:1135-41
Cui, Weina; Zhu, Xiao-Hong; Vollmers, Manda L et al. (2013) Non-invasive measurement of cerebral oxygen metabolism in the mouse brain by ultra-high field (17)O MR spectroscopy. J Cereb Blood Flow Metab 33:1846-9
Lu, Ming; Zhang, Yi; Ugurbil, Kamil et al. (2013) In vitro and in vivo studies of 17O NMR sensitivity at 9.4 and 16.4 T. Magn Reson Med 69:1523-7