The University of Kentucky proposes to acquire an Aperio ScanScope(R) XT digital slide scanner including the ImageScope""""""""/Genie"""""""" and Webscope"""""""" viewing software. This instrument will be housed in the University of Kentucky Alzheimer's Disease Center Neuropathology Core laboratory. The location is safe and secure, but open to all the Major and Minor Users, with outstanding Institutional Support. 11 Major Users and 3 Minor Users, representing ten different academic departments within the University, strongly desire the instrument. There is no analogous instrument currently available within or nearby the University of Kentucky;however, this scientific advancement dovetails very well with existing medical expertise, technical infrastructure, and research facilities at the University of Kentucky. The Aperio ScanScope XT scans and analyzes microscope slides in a digitized format that will enable optimized and detailed archiving and data mining of histopathological data. The instrument represents a significant technological step forward for the field of quantitative neuropathology by facilitating the digitized identification and analysis of histopathological hallmarks of ND, in addition to normal structures. In addition, the slide scanner is ideal for improving quantitative measures of surviving cell counts in stereology, in situ hybridization signal quantification, animal model assessments (including brain trauma and prion disease models), and other cutting edge applications that will directly facilitate NIH-funded research projects by Major Users at the University of Kentucky. This instrument will provide a unique opportunity to introduce, validate, and publish methods in digital microscopy and bioinformatics for the purpose of quantifying brain pathology. The instrument will have an Advisory Panel that is broad-based, with representation by eight different academic departments from the University of Kentucky. Finally, due to its web-based functionality, the purchase of the Aperio ScanScope XT will allow for the exchange of data throughout Kentucky's remote regions and through the network of Alzheimer's Disease Centers nationally.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biomedical Research Support Shared Instrumentation Grants (S10)
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Special Emphasis Panel (ZRG1-CB-J (31))
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Levy, Abraham
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University of Kentucky
Schools of Medicine
United States
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Nelson, Peter T; Jicha, Gregory A; Wang, Wang-Xia et al. (2015) ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target. Ageing Res Rev 24:111-25
Ighodaro, Eseosa T; Jicha, Gregory A; Schmitt, Frederick A et al. (2015) Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature. J Neuropathol Exp Neurol 74:642-52
Neltner, Janna H; Abner, Erin L; Baker, Steven et al. (2014) Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing. Brain 137:255-67
Scheff, Stephen W; Neltner, Janna H; Nelson, Peter T (2014) Is synaptic loss a unique hallmark of Alzheimer's disease? Biochem Pharmacol 88:517-28
Nelson, Peter T; Smith, Charles D; Abner, Erin L et al. (2013) Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease. Acta Neuropathol 126:161-77
Bachstetter, Adam D; Norris, Christopher M; Sompol, Pradoldej et al. (2012) Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology. J Neurosci 32:10201-10
Neltner, Janna Hackett; Abner, Erin Lynn; Schmitt, Frederick A et al. (2012) Digital pathology and image analysis for robust high-throughput quantitative assessment of Alzheimer disease neuropathologic changes. J Neuropathol Exp Neurol 71:1075-85