Endowment funding for Meharry Medical College is sought for three inter-related faculty recruitment initiatives to advance our bench-to-bedside-to-community research in health disparities in our four signature research areas: Cancer, HIV/AIDS, Women's Health, and Brain and Behavior. The specific objectives of the research to be undertaken, which also creates a venue for the training of minority scientists in laboratory, translational, clinical, behavioral, epidemiological, and outcomes research are to:1) Expand our research capacity in HIV/AIDS, Cancer, Women's Health and Brain and Behavior by targeted recruitments that permit synergies among these programs; 2)Target recruitments in the study of human behavior and in interventional strategies to modify behavior to enhance health-serving choices and habits, with behavioral focus on issues related to HIV/AIDS, Women's Health, and Cancer; 3) Expand the cadre of well-trained minority clinician scientists, with special emphasis on clinician-scientists whose research will foster the bench-to-bedside-to community research continuum in our four signature research areas. We also intend to develop a fourth, linked, initiative for training. The junior colleagues to work with our investigators in our four signature research areas, which is to: 4) Strengthen the research infrastructure, particularly for clinical and community based participatory research and for training in these areas to strengthen our signature research focus areas in their bench-to-bedside-community goals, including the creation of a PhD-granting program in Clinical Investigation and expansion of our MSPH program to include training in molecular epidemiology, outcomes, and community-based participatory research to assure our continuum of our health disparities research from the academic health center to the community. ? ? The Five Year Strategic Plan which has laid out the objectives, timetable, actions, and performance and program outcomes is an extension of our 2003-2008 Strategic Plan whose focus has led to accelerated success in addressing Cancer, HIV/AIDS. Women's Health, and Brain and Behavior, all of which represent areas of considerable disparity in disease susceptibility and health outcomes. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Research and Institutional Resources Health Disparities Endowment Grants -Capacity Building (S21)
Project #
5S21MD000104-07
Application #
7272837
Study Section
Special Emphasis Panel (ZMD1-MR (04))
Program Officer
Stinson, Nathaniel
Project Start
2001-09-30
Project End
2009-09-29
Budget Start
2007-09-30
Budget End
2008-09-29
Support Year
7
Fiscal Year
2007
Total Cost
$3,437,500
Indirect Cost
Name
Meharry Medical College
Department
Type
Schools of Medicine
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208
Cheatham, Amber M; Davis, Shamara E; Khatua, Atanu K et al. (2018) Blocking the 5' splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch. Sci Rep 8:8739
Dong, Xin-Hong; Ho, Meng-Hsuan; Liu, Bindong et al. (2018) Role of Porphyromonas gingivalis outer membrane vesicles in oral mucosal transmission of HIV. Sci Rep 8:8812
Suman, Shankar; Rachakonda, Girish; Mandape, Sammed N et al. (2018) Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase. PLoS Negl Trop Dis 12:e0006792
Ignacio, Rosa Mistica C; Gibbs, Carla R; Lee, Eun-Sook et al. (2018) The TGF?-EGFR-Akt signaling axis plays a role in enhancing proinflammatory chemokines in triple-negative breast cancer cells. Oncotarget 9:29286-29303
Walker, Miriam Y; Pratap, Siddharth; Southerland, Janet H et al. (2018) Role of oral and gut microbiome in nitric oxide-mediated colon motility. Nitric Oxide 73:81-88
Shimamoto, Akiko; Rappeneau, Virginie (2017) Sex-dependent mental illnesses and mitochondria. Schizophr Res 187:38-46
Aronoff, David M; Correa, Hernan; Rogers, Lisa M et al. (2017) Placental pericytes and cytomegalovirus infectivity: Implications for HCMV placental pathology and congenital disease. Am J Reprod Immunol 78:
Williams, Amanda D; Korolkova, Olga Y; Sakwe, Amos M et al. (2017) Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One 12:e0179710
Ho, Meng-Hsuan; Lamont, Richard J; Xie, Hua (2017) A novel peptidic inhibitor derived from Streptococcus cristatus ArcA attenuates virulence potential of Porphyromonas gingivalis. Sci Rep 7:16217
Ho, Meng-Hsuan; Lamont, Richard J; Xie, Hua (2017) Identification of Streptococcus cristatus peptides that repress expression of virulence genes in Porphyromonas gingivalis. Sci Rep 7:1413

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