Genomic and other high throughput technologies in the biomedical sciences are generating overwhelming amounts of data that must be processed, analyzed, and interpreted. These massive amounts of data have created a critical need for theoretical, algorithmic, software, and hardware advances in storing, retrieving, networking, processing, modeling, visualizing, and interpreting biological and medical information. These needs continue to inspire new concepts in computer science, such as genetic algorithms, neural networks, computer viruses, and DMA computing methods. Because of these developments, computer science applications in the fields of biology and medicine showcase the latest advances in core computer science from hardware to software, from algorithms to databases, and from theory to user interfaces. This cross fertilization has enriched both fields and will continue to do so in the coming decades. To continue to meet these challenges, the UCI Biomedical Informatics Training (BIT) Program trains graduate students and postdoctoral fellows at the interface of the life and computational sciences for professional careers in bioinformatics and computational biology. The BIT Program, administered by the UCI Institute for Genomics and Bioinformatics, integrates a first year Mathematical and Computational Biology Gateway Program with biomedical informatics training programs in the UCI Schools of Biological and Physical Sciences, Engineering, Medicine, and Information and Computer Sciences. This Program emphasizes interdisciplinary teamwork using a dual mentor approach involving interdisciplinary thesis research projects. Required core courses in mathematics, statistics, and computer science provide students with the computational tools required to address complex biological questions. Regular faculty/trainee meetings, quarterly reviews, and an annual mini-symposium of student projects stimulate interaction, inform faculty of progress, and foster group cohesion as well as interdisciplinary exchange of information among trainees. In summary, the BIT Program is producing a critically-needed generation of world class scholars who will develop new bionformatics and computational biology tools to solve fundamental problems in biology and medicine for the improvement of human health.

National Institute of Health (NIH)
National Library of Medicine (NLM)
Continuing Education Training Grants (T15)
Project #
Application #
Study Section
Special Emphasis Panel (ZLM1-AP-T (O1))
Program Officer
Florance, Valerie
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Irvine
Other Domestic Higher Education
United States
Zip Code
Cinquin, Amanda; Chiang, Michael; Paz, Adrian et al. (2016) Intermittent Stem Cell Cycling Balances Self-Renewal and Senescence of the C. elegans Germ Line. PLoS Genet 12:e1005985
Biehl, Michael; Sadowski, Peter; Bhanot, Gyan et al. (2015) Inter-species prediction of protein phosphorylation in the sbv IMPROVER species translation challenge. Bioinformatics 31:453-61
Cinquin, Amanda; Zheng, Likun; Taylor, Pete H et al. (2015) Semi-permeable Diffusion Barriers Enhance Patterning Robustness in the C. elegans Germline. Dev Cell 35:405-17
Burke, Anthony M; Kandur, Wynne; Novitsky, Eric J et al. (2015) Synthesis of two new enrichable and MS-cleavable cross-linkers to define protein-protein interactions by mass spectrometry. Org Biomol Chem 13:5030-7
Lusci, Alessandro; Browning, Michael; Fooshee, David et al. (2015) Accurate and efficient target prediction using a potency-sensitive influence-relevance voter. J Cheminform 7:63
Guan, Zhiyun; Liu, Haoping (2015) The WOR1 5' untranslated region regulates white-opaque switching in Candida albicans by reducing translational efficiency. Mol Microbiol 97:125-38
Kandur, Wynne V; Kao, Athit; Vellucci, Danielle et al. (2015) Design of CID-cleavable protein cross-linkers: identical mass modifications for simpler sequence analysis. Org Biomol Chem 13:9793-807
Chiang, Michael; Cinquin, Amanda; Paz, Adrian et al. (2015) Control of Caenorhabditis elegans germ-line stem-cell cycling speed meets requirements of design to minimize mutation accumulation. BMC Biol 13:51
Reyes de Mochel, Nabora Soledad; Luong, Mui; Chiang, Michael et al. (2015) BMP signaling is required for cell cleavage in preimplantation-mouse embryos. Dev Biol 397:45-55
Guan, Zhiyun; Liu, Haoping (2015) Overlapping Functions between SWR1 Deletion and H3K56 Acetylation in Candida albicans. Eukaryot Cell 14:578-87

Showing the most recent 10 out of 140 publications