Purpose and Program Characteristics: The purpose of the proposed program is to provide research training for 5 predoctoral (Ph.D.), 3 postdoctoral trainees, and 4 medical students (summer) in biobehavioral approaches to the study of alcohol abuse and alcoholism, with the specific objective of producing competent, independent investigators. Through specific courses, seminars, clinical research practice, and laboratory research, these trainees will: (1) acquire research methodologies relevant to alcohol abuse alcoholism areas; (2) develop an appreciation of the biomedical, biobehavioral and clinical aspects of alcoholism and the acute and chronic effects of alcohol; and (3) apply the latter knowledge base and skills in designing and executing original research in this area. We have identified several research areas for which faculty supervision and research facilities are available: behavioral pharmacology, behavioral genetics, electrophysiology/neurophysiology (both human and animal studies), human performance and neuropsychology, psychophysiology (both human and animal studies), and neurochemistry. Current research opportunities include the following: tolerance and other drug history factors in alcohol reward effects, antiintoxicants and alcohol self-administration, metabolic and oxidative stress factors in acute and chronic alcohol effects, electrophysiological and behavioral characteristics of alcohol withdrawal, the interaction of alcohol, exercise, and family history on cardiovascular reactivity, residual effects of chronic alcohol exposure on human cognitive processes and electrophysiology acute and chronic alcohol effects on auditory/vestibular neural systems and on brain neurochemistry, gender differences in human subjective effects of alcohol, acute alcohol and hangover effects on human performance and mood, and genetic (inbred strain) analyses of behavioral/neurochemical responsiveness to drugs of abuse. Trainees. Postdoctoral candidates will usually have a Ph.D. in clinical or experimental psychology or in some other biomedical specialty or have an M.D. with residency training psychiatry and will be selected on the basis of research potential. Individuals with an M.D. degree and minorities with doctoral degrees applicants will be encouraged to apply. Predoctoral trainees should have strong undergraduate training in psychology and other biological sciences or be candidates for the M.D./Ph.D. program in the College of Medicine. Special effort will be made to recruit minority candidates. Trainees who complete either program will be qualified for research related positions in a number of settings, including academic, medical center, or clinical research programs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA007222-24
Application #
6341451
Study Section
Special Emphasis Panel (ZAA1-DD (02))
Project Start
1978-07-01
Project End
2004-06-30
Budget Start
2001-07-01
Budget End
2004-06-30
Support Year
24
Fiscal Year
2001
Total Cost
$303,815
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Psychiatry
Type
Schools of Medicine
DUNS #
937727907
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Ceballos, Natalie A; Nixon, Sara Jo; Phillips, Julia A et al. (2003) Semantic processing in alcoholics with and without antisocial symptomatology. J Stud Alcohol 64:286-91
Ceballos, Natalie A; Nixon, Sara Jo; Tivis, Rick (2003) Substance abuse-related P300 differences in response to an implicit memory task. Prog Neuropsychopharmacol Biol Psychiatry 27:157-64
Nakonezny, P A; Kowalewski, R B; Ernst, J M et al. (2001) New ambulatory impedance cardiograph validated against the Minnesota Impedance Cardiograph. Psychophysiology 38:465-73
Bedingfield, J B; King, D A; Holloway, F A (1999) Peripheral opioid receptors may mediate a portion of the aversive and depressant effect of EtOH: CPP and locomotor activity. Alcohol 18:93-101
Tivis, L J; Parsons, O A; Nixon, S J (1998) Anger in an inpatient treatment sample of chronic alcoholics. Alcohol Clin Exp Res 22:902-7
Gauvin, D V; Vanecek, S A; Baird, T J et al. (1998) The stimulus properties of two common over-the-counter drug mixtures: dextromethorphan + ephedrine and dextromethorphan + diphenhydramine. J Psychopharmacol 12:84-92
Bedingfield, J B; Holloway, F A (1998) Methylnaltrexone attenuates taste aversion conditioned by low-dose ethanol. Alcohol 15:51-4
Gauvin, D V; Vanecek, S A; Baird, T J et al. (1998) State-dependent stimulus control: cuing attributes of acute cocaine rebound in rats. Exp Clin Psychopharmacol 6:264-73
Gauvin, D V; Briscoe, R J; Baird, T J et al. (1997) Physiological and subjective effects of acute cocaine withdrawal (crash) in rats. Pharmacol Biochem Behav 57:923-34
Gauvin, D V; Briscoe, R J; Baird, T J et al. (1997) Cross-generalization of an EtOH ""hangover"" cue to endogenously and exogenously induced stimuli. Pharmacol Biochem Behav 57:199-206

Showing the most recent 10 out of 34 publications