This request is for continuation of a research training program for 5 qualified post-doctoral U.S. fellows (with M.D. or Ph.D.). The members of our interdisciplinary team (10 M.D.'s and 6 Ph.D.'s) with expertise in ethanol metabolism, hepatology, gastroenterology, pharmacology, biochemistry, pathology, nutrition, immunology, anatomy, psychiatry and psychology, conduct studies on patients as well as experimental models of alcoholic injury; their objective is to investigate the biochemical and structural mechanism of the pathological effects of ethanol in order to improve diagnosis and treatment and to allow for early recognition through the development of biological markers and biochemical tests. The trainees will be given the opportunity to acquire special skills in both clinical and basic research and to learn advanced techniques in biochemistry, molecular biology, pharmacology, electron microscopy, immunology, immuno cytochemistry, cell culture and experimental psychology. In a 2-3 year apprenticeship with one or more of the senior investigators, the trainees will participate in projects selected on the basis of their interest and the relevance and interdisciplinary value of the question raised. The trainees will attend and give seminars and special lectures in the field, contribute to literature (journal club) and manuscript reviews as well as grant applications, present papers at scientific meetings and acquire the skills needed to publish the research findings in reputable peer reviewed journals. These activities are carried out in an intellectual environment enriched by the presence of a score of international fellows, visiting professors and scientists on sabbaticals. The trainees will be selected on the basis of scholastic achievements, commitment to research in alcoholism and academic orientation. The MD's will usually enter the program at the end of their clinical training (residencies in internal medicine or psychiatry). This program is designed to encourage talented young individuals to enter the field of research on alcoholism and should prepare them to contribute successfully to the understanding and ability to handle alcohol problems. Graduate students with clinical training will be allowed to spend 20 % of their time in clinical activities selected to allow them to maintain their acquired clinical skills. The trainees will have office and laboratory space at the Alcohol Research Center (Bronx Veterans Administration Medical Center), the Annenberg building of the Mount Sinai Medical Center and the laboratory of Dr. S. Fisher, North Shore Hospital, New York. They will have access to a ten bed Medical Detoxification Unit (including an outpatient clinic), a Rehabilitation Unit (with a 20 bed ward and a clinic), supporting GI, Liver and Nutrition Units, as well as fully equipped biochemistry, pharmacology, immunology, molecular biology and electron microscopy laboratories. Extensive animal facilities are available with rabbits, mice, rats, deermice, hamsters, baboons and common surgical suites and culture rooms. There are excellent library, computer and statistics support facilities at the Alcohol Research Ctr., the Bronx VA Medical Ctr., the North Shore Medical Ctr. and the Mount Sinai School of Medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA007275-21
Application #
2855746
Study Section
Special Emphasis Panel (SRCA (51))
Program Officer
Purohit, Vishnu
Project Start
1975-07-01
Project End
2002-06-30
Budget Start
1999-07-01
Budget End
2002-06-30
Support Year
21
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029
Lieber, C S; Robins, S J; Li, J et al. (1994) Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology 106:152-9
Li, J; Rosman, A S; Leo, M A et al. (1994) Tissue inhibitor of metalloproteinase is increased in the serum of precirrhotic and cirrhotic alcoholic patients and can serve as a marker of fibrosis. Hepatology 19:1418-23
Ahmed, S; Leo, M A; Lieber, C S (1994) Interactions between alcohol and beta-carotene in patients with alcoholic liver disease. Am J Clin Nutr 60:430-6
Lim Jr, R T; Gentry, R T; Ito, D et al. (1993) First-pass metabolism of ethanol is predominantly gastric. Alcohol Clin Exp Res 17:1337-44
Tsutsumi, M; Lasker, J M; Takahashi, T et al. (1993) In vivo induction of hepatic P4502E1 by ethanol: role of increased enzyme synthesis. Arch Biochem Biophys 304:209-18
Ma, X; Baraona, E; Lieber, C S (1993) Alcohol consumption enhances fatty acid omega-oxidation, with a greater increase in male than in female rats. Hepatology 18:1247-53
Winters, D K; Cederbaum, A I (1992) The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats. Alcohol Alcohol 27:63-70
Winters, D K; Cederbaum, A I (1992) Expression of a catalytically active human cytochrome P-4502E1 in Escherichia coli. Biochim Biophys Acta 1156:43-9
Winters, D K; Cederbaum, A I (1992) Time course characterization of the induction of cytochrome P-450 2E1 by pyrazole and 4-methylpyrazole. Biochim Biophys Acta 1117:15-24
Roine, R P; Gentry, R T; Lim Jr, R T et al. (1991) Effect of concentration of ingested ethanol on blood alcohol levels. Alcohol Clin Exp Res 15:734-8

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