The purpose of this program is to train promising young scientists at the postdoctoral level in the multi disciplinary strategies of molecular, cellular, behavioral, and clinical neuropsychopharmacology. Research on alcohol and other abused drugs requires methodologies that can pinpoint molecular and cellular sites in the brain, and integrate these mechanisms at the system level of analysis. The Scripps Alcohol Research Center (ARC), combined with a very active independent but interactive San Diego Alcohol Research Community, has developed methods for combining biochemical, morphological, physiological and behavioral research to arrive at broad based studies of sites and mechanisms of drug action. These methods permit the pursuit of research lines broadly through such fields as molecular biology, immunocytochemistry, electrophysiologic analysis (in vitro and in vivo), neuroendocrinology, behavioral pharmacology, electroencephalography and event related cortical evoked potential recordings applied to animal and human subjects, and clinical studies. In addition to developing those technical skills in our trainees deemed essential for their transition into career scientists, we also attempt to develop other important skills: creative research expression, critical selection of problems, experimental design, data recording, validation and security, data interpretation, manuscript and grant preparation, and ethical conduct of research. Through our resident senior program staff, visiting senior scientists and courses given in conjunction with local educators, trainees are exposed to a variety of research applications and techniques. Trainees participate in scientific project review conferences, research seminars and journal clubs is well as actively participating in research programs. Each trainee will also receive a course on ethanol neuropsychopharmacology and a course in ethical conduct of research. Both informal and formal recruitment mechanisms are well established and have provided a sufficient number of high quality applicants. Extensive programs are in place for recruitment of minority and for facilitating minority interest in alcohol research. Postdoctoral fellows and other advanced trainees are selected with preferential weighting towards those seeking interdisciplinary methodologies. They are then assigned to one of the Principal Investigators of the training grant who will coordinate their initial research project selections. Depending upon a trainee's prior research skills, collaborations with more than one senior scientist are encouraged.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
2T32AA007456-20
Application #
6471463
Study Section
Special Emphasis Panel (ZAA1-DD (01))
Program Officer
Vanderveen, Ernestine
Project Start
1983-12-01
Project End
2007-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
20
Fiscal Year
2002
Total Cost
$323,323
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Kreisler, A D; Mattock, M; Zorrilla, E P (2018) The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats. Appetite 130:59-69
Varodayan, F P; Khom, S; Patel, R R et al. (2018) Role of TLR4 in the Modulation of Central Amygdala GABA Transmission by CRF Following Restraint Stress. Alcohol Alcohol 53:642-649
Berger, Anthony L; Henricks, Angela M; Lugo, Janelle M et al. (2018) The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System. Biol Psychiatry 84:611-623
Varodayan, Florence P; Sidhu, Harpreet; Kreifeldt, Max et al. (2018) Morphological and functional evidence of increased excitatory signaling in the prelimbic cortex during ethanol withdrawal. Neuropharmacology 133:470-480
Sidhu, Harpreet; Kreifeldt, Max; Contet, Candice (2018) Affective Disturbances During Withdrawal from Chronic Intermittent Ethanol Inhalation in C57BL/6J and DBA/2J Male Mice. Alcohol Clin Exp Res 42:1281-1290
Spierling, Samantha R; Kreisler, Alison D; Williams, Casey A et al. (2018) Intermittent, extended access to preferred food leads to escalated food reinforcement and cyclic whole-body metabolism in rats: Sex differences and individual vulnerability. Physiol Behav 192:3-16
Kirson, Dean; Oleata, Christopher Shaun; Parsons, Loren Howell et al. (2018) CB1 and ethanol effects on glutamatergic transmission in the central amygdala of male and female msP and Wistar rats. Addict Biol 23:676-688
Kimbrough, Adam; de Guglielmo, Giordano; Kononoff, Jenni et al. (2017) CRF1 Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure. Alcohol Clin Exp Res 41:1886-1895
Amodeo, Leslie R; Wills, Derek N; Ehlers, Cindy L (2017) Acute low-level alcohol consumption reduces phase locking of event-related oscillations in rodents. Behav Brain Res 330:25-29
Steinman, Michael Q; Trainor, Brian C (2017) Sex differences in the effects of social defeat on brain and behavior in the California mouse: Insights from a monogamous rodent. Semin Cell Dev Biol 61:92-98

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