The purpose of the training program """"""""Alcoholic Tissue Injury"""""""" is to train qualified postdoctoral and predoctoral fellows in the pathobiology of experimental alcoholic injury. The postdoctoral program has been designed for candidates with a Ph.D., M.D., Sc.D., D.V.M. or D.D.S. degree. The predoctoral program will support candidates in our graduate school who have a B.S. or B.A. degree and who are preparing for a Ph.D. or M.D./Ph.D. degree. All candidates will be selected from a national pool of applicants and must be approved by a training committee before admission. The training committee will also monitor progress in the trainee's research efforts. Predoctoral students who are committed to alcohol-related research will normally be supported through most of their training period. The postdoctoral training period will normally be for two years but may be extended to a third year in exceptional situations. The candidates will receive their training in the department of Pathology and Cell Biology, which occupies 25,000 sq.ft. of research space in Thomas Jefferson University in Philadelphia. Twenty nine faculty members, M.D.'s or Ph.D.'s all of whom have USPHS-supported research projects related to alcoholism, are involved in the training effort. The multidisciplinary approach will emphasize concepts and research techniques of cellular and molecular biology, biophysics, biochemistry and immunology. We anticipate that trainees will develop insight into normal and pathologic processes that are influenced or altered by the presence of ethanol or by chronic alcohol intake. The research projects will be conducted under the auspices of the Alcohol Research Center and will primarily be involved with the effects of ethanol at the cellular and molecular level. In addition to research training in the laboratory, the trainees will attend formal courses, workshops, journal club sessions and seminars given by the staff scientists of the Alcohol Research Center, by other investigators at Thomas Jefferson University and by visiting scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA007463-19
Application #
6771893
Study Section
Special Emphasis Panel (ZAA1-DD (01))
Program Officer
Velazquez, Jose M
Project Start
1986-07-01
Project End
2005-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
19
Fiscal Year
2004
Total Cost
$591,068
Indirect Cost
Name
Thomas Jefferson University
Department
Pathology
Type
Schools of Medicine
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
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Cook, Daniel; Achanta, Sirisha; Hoek, Jan B et al. (2018) Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics. BMC Syst Biol 12:86
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Wang, Guangyu (2017) Mechanistic insight into the heme-independent interplay between iron and carbon monoxide in CFTR and Slo1 BKCa channels. Metallomics 9:634-645
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Schaefer, Liliana; Tredup, Claudia; Gubbiotti, Maria A et al. (2017) Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. FEBS J 284:10-26
Kuttippurathu, Lakshmi; Patra, Biswanath; Cook, Daniel et al. (2017) Pattern analysis uncovers a chronic ethanol-induced disruption of the switch-like dynamics of C/EBP-? and C/EBP-? genome-wide binding during liver regeneration. Physiol Genomics 49:11-26
Torres, Annabel; Gubbiotti, Maria A; Iozzo, Renato V (2017) Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis. J Biol Chem 292:5055-5069

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