This proposal for a T32 training grant is to provide support for pre and postdoctoral trainees in the field of alcohol research at Wake Forest University School of Medicine. We are a group of outstanding, well-funded alcohol investigators with a solid funding base in basic, clinical, human populations research that has been successful for fourteen years in training young scientists to become independent investigators. Our research is carried out in a highly collaborative, multidisciplinary manner so that trainees not only receive the training necessary to become independent investigators, but also as members of interdisciplinary teams of the kind that will increasingly characterize their future research careers. The research training faculty do work that is highly translational. First, virtually all of our studies employ alcohol self-administration. It also spans the scale from mice and rats, through monkeys and individual humans, to human populations. Many of our studies examine the same end points and employ the same behavioral models in multiple species. Training consists of rigorous didactic work along with intensive laboratory-based research. It is augmented by a robust curriculum in career development, including teaching and writing courses, and ethics. There are multiple opportunities for students to hone their presentation skills, including journal clubs and required research seminar presentations at least twice or more each year, depending on which graduate program they are in. We require our students to apply for individual NRSA support both to free up slots on the training grant and to help them hone their skills in grant writing. Training also benefits from distinct school resources that include a Translational Science Institute that offers courses in translational Research, a primate center with several populations of monkeys including a fully pedigreed and genotyped vervet colony, and state of the art imaging. We have also formed a partnership with a local treatment center that will give our students clinical exposure to enhance their understanding of the disease of alcoholism and ground their research in he real world.

Public Health Relevance

The incidence of alcohol abuse and alcoholism remain high in the United States. New drinking patterns, including excessive binge drinking by young people, increase risk of adverse consequences. This training program will supply the United States with highly trained alcohol researchers who are poised to address the serious problems presented by alcoholism.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
2T32AA007565-16
Application #
7629993
Study Section
Special Emphasis Panel (ZAA1-HH (32))
Program Officer
Grandison, Lindsey
Project Start
1994-07-01
Project End
2014-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
16
Fiscal Year
2009
Total Cost
$394,578
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
John, William S; Martin, Thomas J; Solingapuram Sai, Kiran Kumar et al. (2018) Chronic ?9-THC in Rhesus Monkeys: Effects on Cognitive Performance and Dopamine D2/D3 Receptor Availability. J Pharmacol Exp Ther 364:300-310
Deal, Alex L; Konstantopoulos, Joanne K; Weiner, Jeff L et al. (2018) Exploring the consequences of social defeat stress and intermittent ethanol drinking on dopamine dynamics in the rat nucleus accumbens. Sci Rep 8:332
Morales, Melissa; McGinnis, Molly M; Robinson, Stacey L et al. (2018) Chronic Intermittent Ethanol Exposure Modulation of Glutamatergic Neurotransmission in Rat Lateral/Basolateral Amygdala is Duration-, Input-, and Sex-Dependent. Neuroscience 371:277-287
Siciliano, Cody A; Saha, Kaustuv; Calipari, Erin S et al. (2018) Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation. J Neurosci 38:484-497
Siciliano, Cody A; Karkhanis, Anushree N; Holleran, Katherine M et al. (2018) Cross-Species Alterations in Synaptic Dopamine Regulation After Chronic Alcohol Exposure. Handb Exp Pharmacol :
Dobbins, Dorothy L; Klorig, David C; Smith, Thuy et al. (2018) Expression of channelrhodopsin-2 localized within the deep CA1 hippocampal sublayer in the Thy1 line 18 mouse. Brain Res 1679:179-184
Mayhugh, Rhiannon E; Laurienti, Paul J; Fanning, Jason et al. (2018) Cardiac vagal dysfunction moderates patterns of craving across the day in moderate to heavy consumers of alcohol. PLoS One 13:e0200424
Czoty, Paul W; John, William S; Newman, Amy Hauck et al. (2018) Yawning elicited by intravenous ethanol in rhesus monkeys with experience self-administering cocaine and ethanol: Involvement of dopamine D3 receptors. Alcohol 69:1-5
Melchior, James R; Jones, Sara R (2017) Chronic ethanol exposure increases inhibition of optically targeted phasic dopamine release in the nucleus accumbens core and medial shell ex vivo. Mol Cell Neurosci 85:93-104
Luessen, D J; Sun, H; McGinnis, M M et al. (2017) Chronic intermittent ethanol exposure selectively alters the expression of G? subunit isoforms and RGS subtypes in rat prefrontal cortex. Brain Res 1672:106-112

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