Abstract

This competitive renewal application for a training grant requests funds for 9 predoctoral and 9 postdoctoral trainees. The goal is to provide opportunities for research training on molecular genetics approaches to biology and pathology of aging, with special emphasis upon a variety of model organisms and cell cultures that are amenable to genetic analysis (S. cerevisiae, C. elegans, M. domesticus, H. sapiens); such materials should permit trainees to address fundamentaI mechanisms highly relevant to aging and age-related diseases, including Alzheimer's disease (AD) and cancer. Didactic experiences will include courses in biochemistry, genetics, cell biology and pathology, research seminars, journal clubs, reviews of on-going research (approximately 60 individual and 6 program-projects, LEAD or center grants in aging), and a course on """"""""Molecular Genetic Approaches to Aging,"""""""" and bi-monthly """"""""Aging Journal Club."""""""" In addition, trainees will typically participate in weekly lab meetings and in individual conferences with their mentors. Research projects will include efforts to identify genes related to various forms of familial and sporadic AD, delineations of mechanisms of p -amyloidogenesis and of its suppression, the role of the Wemer syndrome helicase gene in aging and cancer, studies of free radical injury and defense in relation to aging, DNA damage and mutation in aging, and mechanisms underlying the limited replicative potential of somatic cells. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
2T32AG000057-26
Application #
6596692
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (J1))
Program Officer
Sierra, Felipe
Project Start
1978-07-01
Project End
2008-04-30
Budget Start
2003-05-01
Budget End
2004-04-30
Support Year
26
Fiscal Year
2003
Total Cost
$724,776
Indirect Cost

  Institution

Name
University of Washington
Department
Pathology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Zabinsky, Rebecca A; Mason, Grace Alexandria; Queitsch, Christine et al. (2018) It's not magic - Hsp90 and its effects on genetic and epigenetic variation. Semin Cell Dev Biol :
Liu, Sophia Z; Ali, Amir S; Campbell, Matthew D et al. (2018) Building strength, endurance, and mobility using an astaxanthin formulation with functional training in elderly. J Cachexia Sarcopenia Muscle 9:826-833
Burnaevskiy, Nikolay; Chen, Shengying; Mailig, Miguel et al. (2018) Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans. Elife 7:
Kramer, Philip A; Duan, Jicheng; Gaffrey, Matthew J et al. (2018) Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle. Redox Biol 17:367-376
Crane, Matthew M; Kaeberlein, Matt (2018) The paths of mortality: how understanding the biology of aging can help explain systems behavior of single cells. Curr Opin Syst Biol 8:25-31
Taylor, Laura M; McMillan, Pamela J; Liachko, Nicole F et al. (2018) Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration. Mol Neurodegener 13:7
Rhea, Elizabeth M; Bullock, Kristin M; Banks, William A (2018) Effect of controlled cortical impact on the passage of pituitary adenylate cyclase activating polypeptide (PACAP) across the blood-brain barrier. Peptides 99:8-13
Rhea, Elizabeth M; Salameh, Therese S; Logsdon, Aric F et al. (2017) Blood-Brain Barriers in Obesity. AAPS J 19:921-930
Miller, Hillary; Fletcher, Marissa; Primitivo, Melissa et al. (2017) Genetic interaction with temperature is an important determinant of nematode longevity. Aging Cell 16:1425-1429
Tryon, Valerie L; Penner, Marsha R; Heide, Shawn W et al. (2017) Hippocampal neural activity reflects the economy of choices during goal-directed navigation. Hippocampus 27:743-758

Showing the most recent 10 out of 210 publications