The aim of this postdoctoral research training program is to provide our trainees with in-depth research experience in areas of exercise physiology that have major relevance to gerontology. It is our goal that on completion of their training, our trainees will have the expertise to perform independent clinical or basic research in an area of exercise physiology that has direct relevance to a) prevention and treatment of chronic diseases such as NIDDM, ISCHD, osteoporosis and hypertension that are major causes of secondary aging, b) maintenance of functional capacity and independence in the elderly, and/or c) the biology of aging. In addition to research training, we endeavor to provide our trainees with a strong general background in exercise physiology and in gerontology. The major component of this training program is research under the supervision of a faculty mentor. The program also includes lectures, research seminars and journal clubs. We are requesting continued funding for six postdoctoral trainees. Our trainees have either a Ph.D. (or comparable doctoral degree) in areas such as exercise physiology, physiology, cell biology, or biochemistry, or an M.D. degree with clinical training and a research interest, preferably, but not necessarily, in gerontology, cardiology, metabolism or preventive medicine. The facilities available for this research training program include a human exercise physiology laboratory and exercise facility, a General Clinical Research Center, a Mass Spectrometry Facility, a Diabetes Research and Training Center, extensive laboratory facilities well equipped for research in biochemistry, physiology, cell biology, and molecular biology, as well as an excellent library.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZAG1-DAG-9 (J1))
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Rossi, Winifred K
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Washington University
Internal Medicine/Medicine
Schools of Medicine
Saint Louis
United States
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Weiss, Edward P; Villareal, Dennis T; Ehsani, Ali A et al. (2012) Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness. Aging Cell 11:876-84
Weiss, Edward P; Villareal, Dennis T; Fontana, Luigi et al. (2011) Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans. Aging (Albany NY) 3:533-42
Weiss, Edward P; Arif, Hassan; Villareal, Dennis T et al. (2008) Endothelial function after high-sugar-food ingestion improves with endurance exercise performed on the previous day. Am J Clin Nutr 88:51-7
Weiss, Edward P; Fields, David A; Mittendorfer, Bettina et al. (2008) Reproducibility of postprandial lipemia tests and validity of an abbreviated 4-hour test. Metabolism 57:1479-85
Weiss, Edward P; Villareal, Dennis T; Racette, Susan B et al. (2008) Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: a randomized controlled trial. Rejuvenation Res 11:605-9
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Racette, Susan B; Weiss, Edward P; Hickner, Robert C et al. (2005) Modest weight loss improves insulin action in obese African Americans. Metabolism 54:960-5