At present 5.3 million US citizens are affected by Alzheimer's disease and countless others are impacted by age-related cognitive decline. The cost of care in the US is currently more than $220 billion annually, and with the increase in cases will grow to an unsupportable $1.2 trillion annually by 2050. The loss of cognitive function will impact the quality of life, the available elderly workforce in the nation and our economic viability. We urgently need to discover new prevention and treatment strategies. Biomedical research and the training of a new generation of scientists devoted to studying the mechanisms associated with aging and age-related disorders hold the greatest promise for identifying strategies that allow individuals to age successfully. Our training program focuses on preparation and instruction in the application of molecular and quantitative approaches to the elucidation of the cellular and molecular mechanisms of age-related neurodegeneration, brain plasticity, and learning and memory. We emphasize training on mechanisms but also the discovery and translation of effective therapeutics including lifestyles such as physical activity. Overall, our training program has five primary features and strengths: 1. A team of innovative and scholarly preceptors who have a strong record of accomplishment for training young scholars and an excellent collaborative environment fostering team science 2. A core set of courses on Brain Aging along with seminars and symposia (eg. ReMIND), training on brain pathology through Clinical-pathological case presentations and a mini-clinical internship 3. A unique environment that allows for students from many departments and programs across the campus to have a customized program of study, an opportunity that a single department based program cannot provide 4. Specific training to help trainees reach their individual career goals that will include Training in Communication skills such as our recent training for students on delivering ?elevator pitches? and brief lay descriptions of research 5. An Individual Development Plan (IDP) to prepare them for their own independent careers in the neurobiology of aging, and continual monitoring to ensure they develop broad understanding of the bench to clinic translation of research to improve the lives of the elderly and ensure sustainably healthcare for the nation. Overall, our Training program in Brain Aging is designed to develop a uniquely trained cadre of investigators who over the years will develop successful careers.

Public Health Relevance

This renewal application seeks continued support for the training of Pre-doctoral and Post-doctoral students in the Neurobiology of Aging. Our program includes laboratory based research, formal courses and seminars, and a mini-clinic residency so that fellows literally gain training from ?bench to bedside?. We aspire to continue to train the next generation of research scientists with an enhanced emphasis on translation of basic research findings to clinical applications in order to delay and treat age-related cognitive decline and neurodegenerative diseases.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Wise, Bradley C
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Irvine
Schools of Medicine
United States
Zip Code
Stark, Shauna M; Reagh, Zachariah M; Yassa, Michael A et al. (2018) What's in a context? Cautions, limitations, and potential paths forward. Neurosci Lett 680:77-87
Najafi, Allison R; Crapser, Joshua; Jiang, Shan et al. (2018) A limited capacity for microglial repopulation in the adult brain. Glia 66:2385-2396
Alaghband, Yasaman; Kramár, Enikö; Kwapis, Janine L et al. (2018) CREST in the Nucleus Accumbens Core Regulates Cocaine Conditioned Place Preference, Cocaine-Seeking Behavior, and Synaptic Plasticity. J Neurosci 38:9514-9526
Torres, Maria D; Garcia, Octavio; Tang, Cindy et al. (2018) Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome. Free Radic Biol Med 114:10-14
Morozko, Eva L; Ochaba, Joseph; Hernandez, Sarah J et al. (2018) Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice. J Huntingtons Dis 7:321-335
Kwapis, Janine L; Alaghband, Yasaman; Kramár, Enikö A et al. (2018) Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. Nat Commun 9:3323
Ng, Chi-Wing; Elias, Gabriel A; Asem, Judith S A et al. (2018) Nonspatial sequence coding varies along the CA1 transverse axis. Behav Brain Res 354:39-47
Reagh, Zachariah M; Noche, Jessica A; Tustison, Nicholas J et al. (2018) Functional Imbalance of Anterolateral Entorhinal Cortex and Hippocampal Dentate/CA3 Underlies Age-Related Object Pattern Separation Deficits. Neuron 97:1187-1198.e4
Franich, Nicholas R; Basso, Manuela; André, Emily A et al. (2018) Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models. J Huntingtons Dis 7:137-150
Holbrook, Andrew; Vandenberg-Rodes, Alexander; Fortin, Norbert et al. (2017) A Bayesian supervised dual-dimensionality reduction model for simultaneous decoding of LFP and spike train signals. Stat (Int Stat Inst) 6:53-67

Showing the most recent 10 out of 115 publications