Abstract

Five years of continuing support totaling $1,645,548 in direct costs are requested for an institutional training program at BUSM for six predoctoral and six postdoctoral fellows. The training focuses on the cellular and molecular biology of aging, with particular emphasis on the biochemistry of aging. This application will merge two previously independent NIA sponsored training programs located in the Departments of Biochemistry and Dermatology, and will include 24 faculty members with research interests in neurobiology, cell growth, cell signaling, connective tissue biochemistry, and genetics. It requests continuation of the combined current number of trainee slots of six predoctoral and six postdoctoral positions. Two of the postdoctoral slots are presently located in the Department of Dermatology training program which will be incorporated into this program. The training includes formal course work, seminars, journal clubs and individual research projects in the areas of cell and molecular biology of aging within a framework of the clinical and epidemiologic aspects of aging. The goal is to train individuals in these areas for both the Ph.D. and M.D./Ph.D. degrees who will later pursue careers as independent investigators in gerontological research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AG000115-15
Application #
2899660
Study Section
Biological and Clinical Aging Review Committee (BCA)
Program Officer
Sierra, Felipe
Project Start
1985-09-01
Project End
2000-04-30
Budget Start
1999-05-01
Budget End
2000-04-30
Support Year
15
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Boston University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Robitsek, Jonathan; Ratner, Marcia H; Stewart, Tara et al. (2015) Combined administration of levetiracetam and valproic acid attenuates age-related hyperactivity of CA3 place cells, reduces place field area, and increases spatial information content in aged rat hippocampus. Hippocampus 25:1541-55
Tran, Thanh H; Shi, Xiaofeng; Zaia, Joseph et al. (2012) Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem 287:32651-64
King, Gwendalyn D; Rosene, Douglas L; Abraham, Carmela R (2012) Promoter methylation and age-related downregulation of Klotho in rhesus monkey. Age (Dordr) 34:1405-19
Kao, Patricia F; Banigan, Meredith G; Vanderburg, Charles R et al. (2012) Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology. J Neuropathol Exp Neurol 71:654-64
King, Gwendalyn D; Chen, CiDi; Huang, Mickey M et al. (2012) Identification of novel small molecules that elevate Klotho expression. Biochem J 441:453-61
Turnbaugh, Jessie A; Unterberger, Ursula; Saá, Paula et al. (2012) The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc). J Neurosci 32:8817-30
Sallum, Christine O; Wilson, Jamie L; Rupasinghe, Chamila et al. (2012) Enhancing and limiting endothelin-1 signaling with a cell-penetrating peptide mimicking the third intracellular loop of the ETB receptor. Chem Biol Drug Des 80:374-81
Pino, Elizabeth; Wang, Hong; McDonald, Meghan E et al. (2012) Roles for peroxisome proliferator-activated receptor ? (PPAR?) and PPAR? coactivators 1? and 1? in regulating response of white and brown adipocytes to hypoxia. J Biol Chem 287:18351-8
Davis, David A; Wilson, Meredith H; Giraud, Jodel et al. (2009) Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth. PLoS Biol 7:e1000208
Lee, Margaret S; Yaar, Mina; Eller, Mark S et al. (2009) Telomeric DNA induces p53-dependent reactive oxygen species and protects against oxidative damage. J Dermatol Sci 56:154-62

Showing the most recent 10 out of 16 publications