Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AG000131-08
Application #
3530323
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
1986-05-01
Project End
1996-04-30
Budget Start
1992-05-01
Budget End
1993-04-30
Support Year
8
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Allegheny University of Health Sciences
Department
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129
Cai, G; Gurdal, H; Smith, C et al. (1999) Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein. Mol Pharmacol 56:989-96
Cristofalo, V J; Allen, R G; Pignolo, R J et al. (1998) Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation. Proc Natl Acad Sci U S A 95:10614-9
Wang, H Y; Pisano, M R; Friedman, E (1994) Attenuated protein kinase C activity and translocation in Alzheimer's disease brain. Neurobiol Aging 15:293-8
De Tata, V; Ptasznik, A; Cristofalo, V J (1993) Effect of the tumor promoter phorbol 12-myristate 13-acetate (PMA) on proliferation of young and senescent WI-38 human diploid fibroblasts. Exp Cell Res 205:261-9
Cristofalo, V J; Pignolo, R J; Cianciarulo, F L et al. (1992) Changes in gene expression during senescence in culture. Exp Gerontol 27:429-32
Snyder, D L; Aloyo, V J; McIlvain, H B et al. (1992) Effect of age on potassium- and tyramine-induced release of norepinephrine from cardiac synaptosomes in male F344 rats. J Gerontol 47:B190-7
DiPaolo, B R; Pignolo, R J; Cristofalo, V J (1992) Overexpression of the two-chain form of cathepsin B in senescent WI-38 cells. Exp Cell Res 201:500-5
Wang, H Y; Pisano, M R; Friedman, E (1992) Age-related alteration in G protein function in rat cortex. Ann N Y Acad Sci 663:426-8
Luce, M C; Cristofalo, V J (1992) Reduction in heat shock gene expression correlates with increased thermosensitivity in senescent human fibroblasts. Exp Cell Res 202:9-16
Frederich, K B; Phillips, P D; Cristofalo, V J (1992) Stimulation of DNA synthesis in senescent human cells following incubation with plasma membranes. Exp Cell Res 202:386-90

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