This is the second renewal of a training grant on Cellular and Neurobiological Aspects of Aging. The training program covers research in the departments of Pathology and Anatomy & Cell Biology, the Center for Neurobiology and Behavior, as well as the Alzheimer's Disease Research Center (ADRC). Many of the faculty, who are part of this training grant are also members of the ADRC, which is headed by Dr. Michael Shelanski. Although there is an emphasis on Alzheimer's Disease, it is not the only focus of this training program. The research interests of the participating faculty include the study of other neurodegenerative diseases, such as Parkinson's Disease, Alexander's Disease and Amyotropic Lateral Sclerosis, as well as cell biological problems, such as the mechanisms of cell death, the dynamics of the cytoskeleton, the cessation of the cell cycle and the action of growth factors and their receptors. One of the strengths of the training program is the wide variety of research interests of the participating faculty, which has enabled us to attract good candidates. We are asking for continued support for four pre-doctoral and four post- doctoral trainees. The pre-doctoral trainees will be chosen from the pool of graduate students who are being trained by the participating faculty and will be selected on the basis of their research interests and qualifications. A Unified Program involving all the graduate programs at Columbia University College of Physicians and Surgeons has recently been instituted. As Part of the Unified Program, all the first year students will be supported by the Office of Graduate Affairs. We are now able to choose among the students who already have selected their mentors. The pool of students available to the participating faculty is large and the qualifications of the students are excellent. In addition to paying for all the first year students, Columbia University is demonstrating their support of the training program by supplementing the salaries of the trainees in order for them to be able to meet the high cost of living in New York. Postdoctoral trainees apply directly to the laboratory of the participating faculty and subsequently apply to be supported by the training grant. The participating faculty members are all funded and have well equipped laboratories with all the research equipment necessary to do high quality cell and molecular biology.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AG000189-13
Application #
6371886
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Wise, Bradley C
Project Start
1990-01-01
Project End
2004-04-30
Budget Start
2001-05-01
Budget End
2002-04-30
Support Year
13
Fiscal Year
2001
Total Cost
$337,619
Indirect Cost
Name
Columbia University (N.Y.)
Department
Pathology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Finkelstein, Erik; Chang, Winston; Chao, P-H Grace et al. (2004) Roles of microtubules, cell polarity and adhesion in electric-field-mediated motility of 3T3 fibroblasts. J Cell Sci 117:1533-45
Mulrenin, E M; Witkin, J W; Silverman, A J (1999) Embryonic development of the gonadotropin-releasing hormone (GnRH) system in the chick: a spatio-temporal analysis of GnRH neuronal generation, site of origin, and migration. Endocrinology 140:422-33
Shanas, U; Bhasin, R; Sutherland, A K et al. (1998) Brain mast cells lack the c-kit receptor: immunocytochemical evidence. J Neuroimmunol 90:207-11
Kentros, C; Hargreaves, E; Hawkins, R D et al. (1998) Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade. Science 280:2121-6
Mandeville, J T; Lawson, M A; Maxfield, F R (1997) Dynamic imaging of neutrophil migration in three dimensions: mechanical interactions between cells and matrix. J Leukoc Biol 61:188-200
Bulinski, J C; McGraw, T E; Gruber, D et al. (1997) Overexpression of MAP4 inhibits organelle motility and trafficking in vivo. J Cell Sci 110 ( Pt 24):3055-64
Nguyen, H L; Chari, S; Gruber, D et al. (1997) Overexpression of full- or partial-length MAP4 stabilizes microtubules and alters cell growth. J Cell Sci 110 ( Pt 2):281-94
Farinelli, S E; Greene, L A (1996) Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support. J Neurosci 16:1150-62
Witkin, J W; Romero, M T (1995) Comparison of ultrastructural characteristics of gonadotropin-releasing hormone neurons in prepubertal and adult male rats. Neuroscience 64:1145-51
Martys, J L; Shevell, T; McGraw, T E (1995) Studies of transferrin recycling reconstituted in streptolysin O permeabilized Chinese hamster ovary cells. J Biol Chem 270:25976-84

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