A program is proposed to provide advanced training to pre-doctoral and postdoctoral fellows in the fundamentals of neuronal plasticity in the aging nervous system. The program has three key features. The first of these is Academic Bridging, whereby a principal focus will be to provide the students and fellows with concepts and research experience which address problems at the interface of basic and clinical problems in aging. This bridging will be reflected in the faculty participating in the program, the students and fellows admitted to the program, and the structure of the training program itself. Seminars and co-sponsorships by basic scientists and clinical researchers of students and fellows will assure that bridging concepts and practice will be emphasized. The second feature is Life Span Development. We believe that the aging process is part of a life span process, which should and can be investigated as part of a continuum from birth to death. Many conceptual and practical problems presently being addressed in early development are translatable to late stage aging. This translation of ideas and approaches from studies of development and adult plasticity will be a feature of the program. In general we believe that investigations of neuronal plasticity are at the very core of understanding late stage aging, since age-related decline often reflects a decrease in neuronal and functional plasticity. Thus understanding the limits and mechanisms of neuronal plasticity will clearly contribute to an understanding of aging and functional decline. In this program we will encourage the participants to address these age-related aspects of plasticity. The third key feature is that the program will be Multidisciplinary. By their very nature Neuroscience and Aging are multidisciplinary fields of investigation. The modern neuroscientist is required to understand and use methods and techniques from the full range of biological disciplines. The faculty in this program represent technical expertise in the fields of Molecular Genetics, Protein Chemistry, Cell Biology, Neurophysiology, Systems Analysis, Behavioral Pharmacology, Computational Neuroscience, and Clinical Neurology. Our goal is to train students to be able to work and think effectively in several of these areas, and this will be achieved by choosing the correct faculty, students, and fellows, and providing them a forum for discussion and interaction.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
2T32AG000216-11
Application #
6454387
Study Section
Special Emphasis Panel (ZAG1-FAS-5 (J1))
Program Officer
Wise, Bradley C
Project Start
1992-09-30
Project End
2007-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
11
Fiscal Year
2002
Total Cost
$490,591
Indirect Cost
Name
University of California San Diego
Department
Neurosciences
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Hsu, Cynthia L; Lee, Elian X; Gordon, Kara L et al. (2018) MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. Nat Commun 9:942
Lake, Blue B; Chen, Song; Sos, Brandon C et al. (2018) Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain. Nat Biotechnol 36:70-80
Urgolites, Zhisen J; Smith, Christine N; Squire, Larry R (2018) Eye movements support the link between conscious memory and medial temporal lobe function. Proc Natl Acad Sci U S A 115:7599-7604
Lee, Ming-Hsiang; Siddoway, Benjamin; Kaeser, Gwendolyn E et al. (2018) Somatic APP gene recombination in Alzheimer's disease and normal neurons. Nature 563:639-645
Devarajan, Priyadharshini; Jones, Michael C; Kugler-Umana, Olivia et al. (2018) Pathogen Recognition by CD4 Effectors Drives Key Effector and Most Memory Cell Generation Against Respiratory Virus. Front Immunol 9:596
Meves, Jessica M; Geoffroy, C├ędric G; Kim, Noah D et al. (2018) Oligodendrocytic but not neuronal Nogo restricts corticospinal axon sprouting after CNS injury. Exp Neurol 309:32-43
Daugherty, Daniel J; Marquez, Alexandra; Calcutt, Nigel A et al. (2018) A novel curcumin derivative for the treatment of diabetic neuropathy. Neuropharmacology 129:26-35
Cheng, Weiwei; Wang, Shaopeng; Mestre, Alexander A et al. (2018) C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2? phosphorylation. Nat Commun 9:51
Adamowicz, David H; Roy, Subhojit; Salmon, David P et al. (2017) Hippocampal ?-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology. J Neurosci 37:1675-1684
Reilly, Patrick; Winston, Charisse N; Baron, Kelsey R et al. (2017) Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation. Neurobiol Dis 106:222-234

Showing the most recent 10 out of 109 publications