This is an application for the renewal of an institutional training grant in Age-Related Cognitive Disorders, first funded by NIA in 2007. The imperative to find better treatments for age-related cognitive and neuropsychiatric diseases requires individuals who are trained in state-of-the-art approaches to these disorders, with a focus on integration and communication across disciplines. To accomplish this, a multidisciplinary program has been developed with four special emphasis areas: (1) Clinical Studies of Age-Related Cognitive and Neuropsychiatric Disorders;(2) Population Studies of Aging and Age-Related Cognitive and Neuropsychiatric Disorders;(3) Imaging Studies of Aging and Age-Related Cognitive and Neuropsychiatric Disorders;and (4) Animal Models of Aging and Neurodegeneration. Both pre-doctoral and post-doctoral trainees are included in the program. A core curriculum is expected of pre-doctoral trainees, with a customized curriculum for post-doctoral trainees. There are 23 participating faculty, drawn from the Departments of Neurology, Psychiatry, Mental Health, Psychology, Radiology, Biostatistics and Geriatrics at Johns Hopkins University. These departments span the School of Medicine, the School of Public Health and the School of Arts and Sciences. In addition, the Division of Geriatrics at Howard University serves as a cooperating site. This framework has allowed us to recruit high-quality trainees. Though in existence for only 4 years, trainees are diverse, have been highly productive, and graduates are in excellent positions at respected institutions. We are therefore requesting to maintain the current level of support (3 pre-doctoral and 3 post-doctoral positions) for the next funding cycle. We believe this program addresses a critical need for training in the area of age-related cognitive and neuropsychiatric disorders, which will ultimately benefit the growing number of older persons who suffer from these conditions.

Public Health Relevance

This is a training program in age-related cognitive and neuropsychiatric disorders. The growing number of older persons who suffer from these conditions requires training young researchers in state-of-the-art approaches to these disorders, with a focus on integration and communication across disciplines.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-3 (J1))
Program Officer
Wagster, Molly V
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Schools of Medicine
United States
Zip Code
Tzuang, Marian; Owusu, Jocelynn T; Spira, Adam P et al. (2018) Cognitive Training for Ethnic Minority Older Adults in the United States: A Review. Gerontologist 58:e311-e324
Walker, Keenan A; Walston, Jeremy; Gottesman, Rebecca F et al. (2018) Midlife Systemic Inflammation is Associated with Frailty in Later Life: The ARIC Study. J Gerontol A Biol Sci Med Sci :
Varma, Vijay R; Oommen, Anup M; Varma, Sudhir et al. (2018) Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study. PLoS Med 15:e1002482
Wang, Yin; Metoki, Athanasia; Alm, Kylie H et al. (2018) White matter pathways and social cognition. Neurosci Biobehav Rev 90:350-370
Walker, Keenan A; Gottesman, Rebecca F; Wu, Aozhou et al. (2018) Association of Hospitalization, Critical Illness, and Infection with Brain Structure in Older Adults. J Am Geriatr Soc 66:1919-1926
Walker, Keenan A; Windham, B Gwen; Brown, Charles H et al. (2018) The Association of Mid- and Late-Life Systemic Inflammation with Brain Amyloid Deposition: The ARIC-PET Study. J Alzheimers Dis 66:1041-1052
Peters, Matthew E; Moussawi, Khaled; Rao, Vani (2018) Teaching Clinical Reasoning with an Example Mnemonic for the Neuropsychiatric Syndromes of Traumatic Brain Injury. Acad Psychiatry 42:686-689
Walker, Keenan A; Windham, B Gwen; Power, Melinda C et al. (2018) The association of mid-to late-life systemic inflammation with white matter structure in older adults: The Atherosclerosis Risk in Communities Study. Neurobiol Aging 68:26-33
Power, Melinda C; Rawlings, Andreea; Sharrett, A Richey et al. (2018) Association of midlife lipids with 20-year cognitive change: A cohort study. Alzheimers Dement 14:167-177
Walker, Keenan A; Power, Melinda C; Hoogeveen, Ron C et al. (2017) Midlife Systemic Inflammation, Late-Life White Matter Integrity, and Cerebral Small Vessel Disease: The Atherosclerosis Risk in Communities Study. Stroke 48:3196-3202

Showing the most recent 10 out of 172 publications