The goal of the Yale Interdisciplinary Immunology Training Program (YIITP) is to equip predoctoral and postdoctoral trainees with the intellectual and research foundations necessary to become independent scientists/educators investigating the immune system and its roles in human disease. The YIITP combines rigorous research training in a highly collaborative, interactive environment with a thorough academic program of instruction in immunology, microbiology, and related disciplines. The program offers training in virtually all aspects of immunology as well as host-pathogen interactions and a variety of autoimmune and inflammatory disorders. Areas of particular strength include innate immune recognition and function, lymphocyte development, immunological tolerance and memory, antigen presentation, immune cell signaling, the immune response to infectious organisms, vascular endothelial cells, cancer immunology, and autoimmune diseases such as Type 1 diabetes, multiple sclerosis, and systemic lupus erythematosus. The 35 YIITP mentors, who have primary appointments in 8 different Yale departments, have an outstanding record of research accomplishment and training and many are leaders in their fields. The YIITP is overseen by the Program Director, David Schatz, and an Executive Committee of four additional faculty members. The principal training entity is the Department of Immunobiology, whose graduate program was the top ranked immunology graduate program in the United States in a 2010 National Research Council study. All students admitted to the YIITP have at least a Bachelor's degree in a relevant field and enter via application to the Yale interdepartmental program in Biological and Biomedical Sciences (BBS). Postdocs enter from the labs of YIITP faculty, and hold a Ph.D. and/or M.D. degree. Predoctoral training leading to the Ph.D. degree involves formal course work in Immunology and other areas of biology, research rotations, teaching, and the qualifying exam in the first two years, with dissertation research beginning late in year one and becoming the primary focus of activity after completion of the qualifying exam. Postdoctoral training focuses intensively on research in the laboratory of one or more of the mentors. Both predoctoral and postdoctoral training are enriched by intensive training in the methods, logic, and responsible conduct of research, and by the many opportunities for collaboration and interaction. The vast majority of YIITP trainees go on obtain independent research and teaching positions at academic institutions or research positions in biotechnology companies. Extensive efforts are made by YIITP mentors and Yale Graduate and Medical Schools to attract and retain trainees from diverse backgrounds, particularly under-represented minority groups. This proposal requests continued support for 10 predoctoral and 3 postdoctoral trainees who will be supported by this grant for a maximum of 2 years. A major recent improvement in the program comes in the form of full institutional support from Yale for first year graduate students, allowing YIITP funding to be restricted to 2nd and 3rd year students.

Public Health Relevance

The Interdisciplinary Immunology Training Program at Yale University supports the education and training of the next generation of scientists who will study the immune system, the system of the body responsible for combating infectious diseases. Graduates from this program go on to leading positions in universities and industry, where they contribute to finding new vaccines, new therapies to combat viruses and bacteria, and new treatments for autoimmune diseases such as diabetes, lupus, and rheumatoid arthritis and hypersensitivity disorders such as asthma.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007019-40
Application #
8852035
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Gondre-Lewis, Timothy A
Project Start
1976-07-01
Project End
2016-08-31
Budget Start
2015-09-01
Budget End
2016-08-31
Support Year
40
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Yale University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
Fistonich, Chris; Zehentmeier, Sandra; Bednarski, Jeffrey J et al. (2018) Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development. J Exp Med 215:2586-2599
Jurado, Kellie A; Yockey, Laura J; Wong, Patrick W et al. (2018) Antiviral CD8 T cells induce Zika-virus-associated paralysis in mice. Nat Microbiol 3:141-147
Molony, Ryan D; Malawista, Anna; Montgomery, Ruth R (2018) Reduced dynamic range of antiviral innate immune responses in aging. Exp Gerontol 107:130-135
Perry, Curtis J; Muñoz-Rojas, Andrés R; Meeth, Katrina M et al. (2018) Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. J Exp Med 215:877-893
Zhou, Xu; Franklin, Ruth A; Adler, Miri et al. (2018) Circuit Design Features of a Stable Two-Cell System. Cell 172:744-757.e17
Manfredo Vieira, S; Hiltensperger, M; Kumar, V et al. (2018) Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science 359:1156-1161
Greiling, Teri M; Dehner, Carina; Chen, Xinguo et al. (2018) Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus. Sci Transl Med 10:
Yockey, Laura J; Jurado, Kellie A; Arora, Nitin et al. (2018) Type I interferons instigate fetal demise after Zika virus infection. Sci Immunol 3:
Pompura, Saige L; Dominguez-Villar, Margarita (2018) The PI3K/AKT signaling pathway in regulatory T-cell development, stability, and function. J Leukoc Biol :
Uraki, Ryuta; Hwang, Jesse; Jurado, Kellie Ann et al. (2017) Zika virus causes testicular atrophy. Sci Adv 3:e1602899

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