The landmark lOM report, """"""""Emerging Infections: Microbial Threats to Health in the United States"""""""" highlighted the importance of studying Infectious diseases in natural animal hosts-60% of all human pathogens are directly transmitted from or emergent from animal reservoirs. Understanding the behavior of pathogens in their natural hosts, including mechanisms of persistence, evolution of virulence, acquisition and maintenance of antimicrobial resistance, and genetic change underlying transmission phenotypes, is now widely recognized as critically important to addressing emerging infections. The broad spectrum of microbial pathogens, from small RNA viruses to multicellular parasites, which infect domestic and wild animals, provides a rich opportunity to understand pathogen behavior in their natural hosts both as models for human disease as well as for directly understanding pathogen evolution and transmission to humans. Our program specifically and uniquely addresses this need and integrates clinically trained veterinarians with post-PhD fellows to provide a rigorous and dynamic training environment. Prominent examples of T32 trainee success in the past 10 years include: i) 7 trainees transitioned to individual K08 (post-DVMs) or F32 (post-PhD) awards;ii) 10 post-DVM trainees received the PhD (4 remain in training);and iii) all past trainees continue in research and there is clear evidence of progressive career advancement. The program has two types of trainees: (i) clinically-trained veterinarians, usually with residency training in clinical microbiology, internal medicine, or pathology;and (ii) post-PhD fellows who expand and enhance their research capabilities in infectious diseases. Critically, both groups of trainees are integrated in the laboratory research training phase with shared trainee led research-in-progress seminars, shared trainee led outside speaker seminars, and in the responsible conduct of research progression. This integration significantly enhances the training environment as each type of trainee brings unique strengths. We propose to continue training 5 fellows per year (3 post-DVM;2 post-PhD) with a minimum of 3 years of dedicated laboratory research for the clinically trained fellows and at least 2 years for post-PhD fellows.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
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Washington State University
Veterinary Sciences
Schools of Veterinary Medicine
United States
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Pastenkos, Gabrielle; Lee, Becky; Pritchard, Suzanne M et al. (2018) Bovine Herpesvirus 1 Entry by a Low-pH Endosomal Pathway. J Virol 92:
Mao, Peng; Brown, Alexander J; Esaki, Shingo et al. (2018) ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma. Nat Commun 9:2626
Gourley, Christopher R; Negretti, Nicholas M; Konkel, Michael E (2017) The food-borne pathogen Campylobacter jejuni depends on the AddAB DNA repair system to defend against bile in the intestinal environment. Sci Rep 7:14777
Wudiri, George A; Nicola, Anthony V (2017) Cellular Cholesterol Facilitates the Postentry Replication Cycle of Herpes Simplex Virus 1. J Virol 91:
Mosites, Emily; Aol, George; Otiang, Elkanah et al. (2017) Child height gain is associated with consumption of animal-source foods in livestock-owning households in Western Kenya. Public Health Nutr 20:336-345
Miller, Cheryl N; Smith, Erin P; Cundiff, Jennifer A et al. (2017) A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication. Cell Host Microbe 22:317-329.e7
Mosites, Emily; Sammons, Matt; Otiang, Elkanah et al. (2017) Microbiome sharing between children, livestock and household surfaces in western Kenya. PLoS One 12:e0171017
Omulo, Sylvia; Thumbi, Samuel M; Lockwood, Svetlana et al. (2017) Evidence of superficial knowledge regarding antibiotics and their use: Results of two cross-sectional surveys in an urban informal settlement in Kenya. PLoS One 12:e0185827
Klein, Jessica A; Powers, TuShun R; Knodler, Leigh A (2017) Measurement of Salmonella enterica Internalization and Vacuole Lysis in Epithelial Cells. Methods Mol Biol 1519:285-296
Negretti, Nicholas M; Gourley, Christopher R; Clair, Geremy et al. (2017) The food-borne pathogen Campylobacter jejuni responds to the bile salt deoxycholate with countermeasures to reactive oxygen species. Sci Rep 7:15455

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