This training grant, currently in its 40th year of funding, represents the primary support for graduate students in the Immunology Training Program at the University of Chicago. The program functions in a diverse environment where the basic biological sciences and the medical school are integrated within the same division in a single campus in Hyde Park, Chicago, IL. It is embodied by the Committee on Immunology, an interdisciplinary and interdepartmental academic unit that serves as the scientific community for immunology graduate students, postdocs, and faculty at the University. The faculty of our Training Program is composed of 34 distinguished trainers selected for their outstanding research and training records, their well- funded laboratories and their dynamic involvement in all aspects of the program. They form a diverse, age- and gender-balanced group whose research spans a broad spectrum of modern areas of immunology including cellular and molecular immunology, biochemistry, genomics, systems biology, microbiome studies, molecular engineering, and human immunology, with a proven record of interdisciplinary collaborations. New strength is drawn from the recent recruitment of five internationally recognized senior faculty with expertise in immunoengineering and immunogenetics, as well as three junior faculty with expertise in systems immunology, mucosal immunology, and myeloid disorders. Predoctoral students receive advanced training through courses focused on the critical analysis of primary literature and experimental design, with special emphasis on computational skills, rigor and reproducibility, and the responsible conduct of research. The comprehensive training includes a weekly Seminar Series, Work-in-Progress forum, and Journal Club, as well as an annual Joint Immunology Retreat held with other top immunology programs in the Midwest. Career development is enhanced through MyChoice, an institutional program enabling trainees to further develop academic skills and gain exposure to a broad array of research-intensive career paths, as well as a partnership with the UChicago Polsky Center for Entrepreneurship and Innovation. The Biological Sciences Division provides strong institutional support, as shown by sustained financial and administrative support, the operation of cutting-edge core facilities such as gnotobiotics, and the implementation of major initiatives such as the Duchossois Family Institute, a new research institute aimed at harnessing the power of the microbiome and immunity for human health. The Program is continuously and rigorously evaluated with respect to organization, leadership, objectives and outcomes. This is one of the most outstanding and competitive training programs in the country, as shown by the high retention and completion rates of our trainees (which include many students from underrepresented minority backgrounds), their impressive publication rate (average of six publications per trainee, including many first-author publications in journals such as Nature, Immunity, Cell Host & Microbe, JEM, and PNAS), and their success in securing independent scientific careers.

Public Health Relevance

This program trains the next generation of immunologists who will lead the innovative research, teaching, and biomedical entrepreneurship that is needed to advance basic science and develop new translational approaches for the prevention and treatment of autoimmune diseases and cancer, the improvement of organ transplantation, and the design of new and more effective vaccines. The funding will contribute to public health by supporting the training of highly skilled individuals who will join the national biomedical research workforce.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Allergy, Immunology, and Transplantation Research Committee (AITC)
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Gondre-Lewis, Timothy A
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University of Chicago
Schools of Arts and Sciences
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Chao, Jaime L; Savage, Peter A (2018) Unlocking the Complexities of Tumor-Associated Regulatory T Cells. J Immunol 200:415-421
Brown, Hailey M; Biering, Scott B; Zhu, Allen et al. (2018) Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon-Inducible GTPases. Bioessays 40:e1700231
An, Ningfei; Khan, Saira; Imgruet, Molly K et al. (2018) Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS. Blood 131:2682-2697
Horton, Brendan L; Williams, Jason B; Cabanov, Alexandra et al. (2018) Intratumoral CD8+ T-cell Apoptosis Is a Major Component of T-cell Dysfunction and Impedes Antitumor Immunity. Cancer Immunol Res 6:14-24
Coers, Jörn; Brown, Hailey M; Hwang, Seungmin et al. (2018) Partners in anti-crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense. Curr Opin Immunol 54:93-101
Kang, Soowon; Brown, Hailey M; Hwang, Seungmin (2018) Direct Antiviral Mechanisms of Interferon-Gamma. Immune Netw 18:e33
Biering, Scott B; Choi, Jayoung; Halstrom, Rachel A et al. (2017) Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases. Cell Host Microbe 22:74-85.e7
Bouziat, Romain; Hinterleitner, Reinhard; Brown, Judy J et al. (2017) Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science 356:44-50
Williams, Jason B; Horton, Brendan L; Zheng, Yan et al. (2017) The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment. J Exp Med 214:381-400
Neu, Karlynn E; Tang, Qingming; Wilson, Patrick C et al. (2017) Single-Cell Genomics: Approaches and Utility in Immunology. Trends Immunol 38:140-149

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