The Infectious Disease Pathogenesis Research Training Program at the University of North Carolina at Chapel Hill develops independent scientists with expertise in biological, epidemiological, and translational research in the pathogenesis of infectious agents. We seek continued support to build further upon 35 years of continuous funding and productivity. The Program is anchored by training mentors from the Schools of Medicine and Public Health, and distinguished by the recruitment of talented trainees to specific research programs. We continue to receive applications from excellent candidates that exceed our training capacity. We propose to support the training of four postdoctoral fellows per year, a roughly equal number of MD or MD PhD, and PhD investigators, to foster the scientific expertise to understand the pathogenesis and control of infectious diseases, and the career skills required contribute to biomedical advancements in challenging times. Some trainees will choose to receive formal training in methods of public health or molecular biology research. All trainees will participate in the course, Responsible Conduct of Research. In this application we report on the training of 27 postdoctoral fellows (18 PhDs, 5 MDs, 4 MD/PhDs) in the past 10 years, including 11 women and 3 African Americans. Most trainees have made excellent progress since leaving the Program, and have received extramural federal funding to support their research. In this renewal we have included 8 new faculty, representing the growth of the infectious disease community at UNC, and exciting new areas of research. We offer a broad range of research opportunities, including work in international settings (e.g. Malawi and Zambia), emerging pathogens/biothreats, and extensive resources to facilitate translational studies. Trainees will also benefit from greatly expanded research space on campus due to ongoing construction and recruitment. In summary, we believe the mentors, the trainees and the environment are well suited to support the goals of the application, and ongoing critical research issues in the pathogenesis and epidemiology of infectious diseases.

Public Health Relevance

The Infectious Disease Pathogenesis Research Training Program seeks to train postdoctoral trainees to conduct outstanding research in the fields of bacterial pathogenesis, immunology, virology and epidemiology of infectious disease pathogenesis, to foster the development of skills necessary to conduct productive interdisciplinary research, and to facilitate professional growth and development to ensure academic and research success.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007151-39
Application #
9256389
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
1978-07-01
Project End
2019-05-31
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
39
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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Witt, Russell G; Kreger, Emily M; Buckman, Laura B et al. (2018) Systemic multilineage engraftment in mice after in utero transplantation with human hematopoietic stem cells. Blood Adv 2:69-74
Boyce, Ross M; Hathaway, Nick; Fulton, Travis et al. (2018) Reuse of malaria rapid diagnostic tests for amplicon deep sequencing to estimate Plasmodium falciparum transmission intensity in western Uganda. Sci Rep 8:10159
Cheng, Ning; Watkins-Schulz, Rebekah; Junkins, Robert D et al. (2018) A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1-insensitive models of triple-negative breast cancer. JCI Insight 3:
Zhou, Shuntai; Williford, Sara E; McGivern, David R et al. (2018) Evolutionary pathways to NS5A inhibitor resistance in genotype 1 hepatitis C virus. Antiviral Res 158:45-51
Wang, Lawrence T; Bwambale, Robert; Keeler, Corinna et al. (2018) Private sector drug shops frequently dispense parenteral anti-malarials in a rural region of Western Uganda. Malar J 17:305
McNamara, Ryan P; Costantini, Lindsey M; Myers, T Alix et al. (2018) Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses. MBio 9:
Widman, Douglas G; Young, Ellen; Yount, Boyd L et al. (2017) A Reverse Genetics Platform That Spans the Zika Virus Family Tree. MBio 8:
Swanson, Karen V; Junkins, Robert D; Kurkjian, Cathryn J et al. (2017) A noncanonical function of cGAMP in inflammasome priming and activation. J Exp Med 214:3611-3626
Palacios, Michelle; Broberg, Christopher A; Walker, Kimberly A et al. (2017) A Serendipitous Mutation Reveals the Severe Virulence Defect of a Klebsiella pneumoniae fepB Mutant. mSphere 2:

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