Abstract

This application is for renewed support for the Training Program in Microbiology for Infectious Diseases, first funded in 1977. We seek to provide trainees with the experimental breadth and biological perspective to produce a new generation of dynamic contributors to research in Microbiology and Infectious Diseases. The 21 members of our Program Faculty have research programs that focus on Immunology (Calame, Clynes, Gu, Reizis, Rothman, Schindler, Zou), Pathogen Biology (Figurski, Goff, Luban, Mitchell, Racaniello, Shuman, Silverstein, Young), and Model Systems (Carlson, Chang, Gottesman, Rothstein, Symington, Waldburger) that pertain to understanding both pathogen and host. Our lecture and seminar courses provide training in basic biological principles and in Immunology, Virology, and Microbial Pathogenesis. Students from several biomedical science graduate programs enter labs of our Program Faculty, and we will choose trainees for support based on their commitment to Microbiology and our evaluation of their academic performance. Thus we will be able to choose the students whose interests parallel our training objectives and whose academic and research accomplishments predict continued success. Among 27 predoctoral trainees who received a Ph.D. in Microbiology in the reporting period, 2 are Assistant Professors, 1 is an Instructor, 14 are postdocs, 2 are science writers, and 8 have gone on to other careers. Among 8 supported postdoctoral trainees, 3 are now tenure-track Assistant Professors. Our program remains dynamic. It has been modified in response to scientific advances, to our refined understanding of the needs of trainees, to changes in graduate program structure at Columbia, and to the scientific evolution of our faculty. Yet the goals enunciated in our original application over 25 years ago remain our goals today: (1) to provide a broad and sound education in the molecular biology and genetics of infectious disease and host responses, and (2) to provide rigorous research training in an environment dedicated to advancing biomedical science. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007161-29
Application #
7278629
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
1978-09-01
Project End
2009-08-31
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
29
Fiscal Year
2007
Total Cost
$237,304
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Cervantes-Barragan, Luisa; Lewis, Kanako L; Firner, Sonja et al. (2012) Plasmacytoid dendritic cells control T-cell response to chronic viral infection. Proc Natl Acad Sci U S A 109:3012-7
Rasmussen, Angela L; Racaniello, Vincent R (2011) Selection of rhinovirus 1A variants adapted for growth in mouse lung epithelial cells. Virology 420:82-8
Lewis, Kanako L; Caton, Michele L; Bogunovic, Milena et al. (2011) Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity 35:780-91
Ghosh, Hiyaa S; Cisse, Babacar; Bunin, Anna et al. (2010) Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells. Immunity 33:905-16
Hovel-Miner, Galadriel; Faucher, Sebastien P; Charpentier, Xavier et al. (2010) ArgR-regulated genes are derepressed in the Legionella-containing vacuole. J Bacteriol 192:4504-16
Bar-On, Liat; Birnberg, Tal; Lewis, Kanako L et al. (2010) CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proc Natl Acad Sci U S A 107:14745-50
Rosenfeld, Amy B; Racaniello, Vincent R (2010) Components of the multifactor complex needed for internal initiation by the IRES of hepatitis C virus in Saccharomyces cerevisiae. RNA Biol 7:596-605
Hovel-Miner, Galadriel; Pampou, Sergey; Faucher, Sebastien P et al. (2009) SigmaS controls multiple pathways associated with intracellular multiplication of Legionella pneumophila. J Bacteriol 191:2461-73
Drahos, Jennifer; Racaniello, Vincent R (2009) Cleavage of IPS-1 in cells infected with human rhinovirus. J Virol 83:11581-7
Sebastian, Sarah; Grutter, Christian; Strambio de Castillia, Caterina et al. (2009) An invariant surface patch on the TRIM5alpha PRYSPRY domain is required for retroviral restriction but dispensable for capsid binding. J Virol 83:3365-73

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