This application is for support of a training program in Allergy and Clinical Immunology for post-doctoral medical and pediatric trainees at Yale University School of Medicine. There is a double training faculty of firstly, clinician-researchers in the Department of Medicine, in the Sections of Allergy, Clinical Immunology, Rheumatology, and Infectious Diseases, and also in Pediatrics; and a basic sciences immunology training faculty in the Department of Immunobiology. The faculty's expertise spans nearly all of the areas important to allergy and clinical immunology, and modern immunology, including: cellular, molecular, biochemical, antigen- processing, presenting, and signaling research. There are several faculty with special expertise in Lyme disease, that was discovered at Yale by one of our fellows under this training program. There is comprehensive training in both medical and pediatric aspects of Allergy, and Clinical immunology, as well as Rheumatology, Dermatology, Gastroenterology. Pulmonary, and ENT. The group is well equipped with major instruments including: 3 cytoflourographs, an oligonucleotide synthesizer, peptide protein sequinator and numerous gamma and beta counters, and diverse computers. This is a small training program with a large faculty taking only one new fellow per year, emphasizing the need for a minimum of 3-5 years laboratory training for preparation for positions in research medicine. The faculty have a strong record in training, collaborative research; especially training of individuals under this Allergy and Clinical Immunology Training Grant. The fellows spend most of their first year engaged in various clinical activities, and the second and third years are spent almost entirely in the laboratory under the guidance of a mentor developing an individual research program, while taking various immunobiology courses, participation in weekly seminars and journal clubs, and regularly giving talks on their research, and on subjects of mutual interest. In summary, the program offers a unique and high quality basis for superb training of outstanding candidates for future positions in academic medicine and pediatrics, and as such as been most successful over more than 25 years of continuous funding.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007174-18
Application #
2671509
Study Section
Special Emphasis Panel (ZAI1-DET-I (91))
Project Start
1980-09-01
Project End
2001-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
18
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Nazimek, Katarzyna; Bryniarski, Krzysztof; Askenase, Philip W (2016) Functions of Exosomes and Microbial Extracellular Vesicles in Allergy and Contact and Delayed-Type Hypersensitivity. Int Arch Allergy Immunol 171:1-26
Kawikova, Ivana; Askenase, Philip W (2015) Diagnostic and therapeutic potentials of exosomes in CNS diseases. Brain Res 1617:63-71
Bryniarski, Krzysztof; Ptak, Wlodzimierz; Martin, Emilia et al. (2015) Free Extracellular miRNA Functionally Targets Cells by Transfecting Exosomes from Their Companion Cells. PLoS One 10:e0122991
Askenase, Phillip W; Bryniarski, Krzysztof; Paliwal, Vipin et al. (2015) A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance. Ann N Y Acad Sci 1362:200-14
Vieira, S M; Pagovich, O E; Kriegel, M A (2014) Diet, microbiota and autoimmune diseases. Lupus 23:518-26
Bantz, Selene K; Zhu, Zhou; Zheng, Tao (2014) The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma. J Clin Cell Immunol 5:
Majewska-Szczepanik, Monika; Paust, Silke; von Andrian, Ulrich H et al. (2013) Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-?, interferon-? and interleukin-12. Immunology 140:98-110
De, Bishnu P; Pagovich, Odelya E; Hicks, Martin J et al. (2013) Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity. Hum Gene Ther 24:58-66
Bryniarski, Krzysztof; Ptak, Wlodzimierz; Jayakumar, Asha et al. (2013) Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity. J Allergy Clin Immunol 132:170-81
Dey, N; Szczepanik, M; Lau, K et al. (2011) Stimulatory lipids accumulate in the mouse liver within 30 min of contact sensitization to facilitate the activation of Naïve iNKT cells in a CD1d-dependent fashion. Scand J Immunol 74:52-61

Showing the most recent 10 out of 19 publications