application): This application is for support of a training program in Allergy and Clinical Immunology, that is designed for post-doctoral medical and pediatric trainees at Yale University School of Medicine. There is a double training faculty of firstly, clinician-researchers in the Department of Medicine, in the Sections of Allergy, and Clinical Immunology, Rheumatology, Pulmonary, and Infectious Diseases, and also in Pediatrics; and secondly, a basic sciences immunology training faculty in the Department of Immunobiology. The faculty's expertise spans the areas important to allergy, clinical immunology, and modern immunology; including: cellular, molecular, biochemical, antigen-processing/presenting, and signaling research. Some faculty are experts in Lyme disease, which was discovered at Yale in this training program. There is training in both medical and pediatric aspects of Allergy, and Clinical immunology, and also some training in Rheumatology, Dermatology, Gastroenterology, Pulmonary, and ENT. The training faculty is well equipped with major instruments including: 4 cytofluorographs, an oligonucleotide synthesizer, and peptide protein sequinator. This is a small training program, taking only one new fellow per year, with a large faculty emphasizing the need for at least of 3-5 years of research laboratory training to prepare trainees for positions in research medicine. The faculty have a strong training record and collaborative research interactions; especially under this Allergy and Clinical Immunology Training Grant. The fellows spend most of their first year engaged in clinical activities. The 2nd and 3rd years are spent almost entirely in the laboratory developing a research program, under the guidance of a faculty mentor, taking various immunobiology courses, participating in weekly seminars and journal clubs, and regularly giving talks on their research, and on subjects of mutual interest. The program offers unique and high quality training for future positions in academic medicine and pediatrics, and has been successful over more than 20 years of continuous funding.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007174-25
Application #
6915788
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
1980-09-01
Project End
2006-07-31
Budget Start
2005-07-01
Budget End
2006-07-31
Support Year
25
Fiscal Year
2005
Total Cost
$180,261
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Nazimek, Katarzyna; Bryniarski, Krzysztof; Askenase, Philip W (2016) Functions of Exosomes and Microbial Extracellular Vesicles in Allergy and Contact and Delayed-Type Hypersensitivity. Int Arch Allergy Immunol 171:1-26
Bryniarski, Krzysztof; Ptak, Wlodzimierz; Martin, Emilia et al. (2015) Free Extracellular miRNA Functionally Targets Cells by Transfecting Exosomes from Their Companion Cells. PLoS One 10:e0122991
Askenase, Phillip W; Bryniarski, Krzysztof; Paliwal, Vipin et al. (2015) A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance. Ann N Y Acad Sci 1362:200-14
Kawikova, Ivana; Askenase, Philip W (2015) Diagnostic and therapeutic potentials of exosomes in CNS diseases. Brain Res 1617:63-71
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Majewska-Szczepanik, Monika; Paust, Silke; von Andrian, Ulrich H et al. (2013) Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-?, interferon-? and interleukin-12. Immunology 140:98-110
De, Bishnu P; Pagovich, Odelya E; Hicks, Martin J et al. (2013) Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity. Hum Gene Ther 24:58-66
Bryniarski, Krzysztof; Ptak, Wlodzimierz; Jayakumar, Asha et al. (2013) Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity. J Allergy Clin Immunol 132:170-81
Dey, N; Szczepanik, M; Lau, K et al. (2011) Stimulatory lipids accumulate in the mouse liver within 30 min of contact sensitization to facilitate the activation of Naïve iNKT cells in a CD1d-dependent fashion. Scand J Immunol 74:52-61

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