The goal of the Training Program in Inflammatory and Immunological Diseases at the Duke University Medical Center is to provide training for young investigators committed to a career in clinical or basic research relevant to the pathogenesis of autoimmune and inflammatory disease in children and adults. The program will be centered in the Divisions of Adult and Pediatric Rheumatology at Duke and will recruit two trainees each year to embark on intensive training in research that will enable them to establish independent investigative careers. The primary focus of the program will be on M.D. and M.D./Ph.D. physicians who have obtained clinical training in rheumatology or one of the related subspecialties that cares for patients with immune-mediated diseases. In addition to training physicians, we will also consider for our program outstanding Ph.D investigators with a commitment to relevant immunological research and the skills and interests in translational approaches. The program is under the direction of Dr. David Pisetsky, Professor of Medicine and Immunology, and Chief of Rheumatology at Duke and Dr. Laura Schanberg, Associate Professor of Pediatrics and Co-Chief of Pediatric Rheumatology. The training faculty of the program is comprised of investigators who are expert in basic and translational research and are pursuing active and productive programs in rheumatology and immunology. Training will consist primarily of an intensive research experience under the supervision of a faculty mentor in concert with a mentoring committee including a core faculty member;formal course work through the graduate school;as well as seminars and journal clubs. In addition, clinical training in adult and/or pediatric rheumatology will be afforded by participation in large inpatient, outpatient and consult services at Duke University Medical Center and Durham VA Hospital. Fulfillment of the goal of this program will meet the great need for physician-scientists and other investigators who are skilled in patient-oriented and disease-oriented research. These individuals will be able to translate new knowledge in basic immunology into advances that will improve the diagnosis and treatment of patients with rheumatologic and immunologic diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007217-28
Application #
7828203
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
1980-09-30
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
28
Fiscal Year
2010
Total Cost
$94,995
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Wu, E Y; Schanberg, L E; Wershba, E C et al. (2017) Lenalidomide for refractory cutaneous manifestations of pediatric systemic lupus erythematosus. Lupus 26:646-649
Carr, Tiffany M; Wheaton, Joshua D; Houtz, Geoffrey M et al. (2017) JunB promotes Th17 cell identity and restrains alternative CD4+ T-cell programs during inflammation. Nat Commun 8:301
Lewandowski, Laura B; Watt, Melissa H; Schanberg, Laura E et al. (2017) Missed opportunities for timely diagnosis of pediatric lupus in South Africa: a qualitative study. Pediatr Rheumatol Online J 15:14
Zhang, Cecilia J; Bidlingmaier, Martin; Altaye, Mekibib et al. (2017) Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans. Eur J Endocrinol 176:123-132
Lewandowski, L B; Schanberg, L E; Thielman, N et al. (2017) Severe disease presentation and poor outcomes among pediatric systemic lupus erythematosus patients in South Africa. Lupus 26:186-194
Lozoya, Oswaldo A; Gilchrist, Christopher L; Guilak, Farshid (2016) Universally Conserved Relationships between Nuclear Shape and Cytoplasmic Mechanical Properties in Human Stem Cells. Sci Rep 6:23047
Cronan, Mark R; Beerman, Rebecca W; Rosenberg, Allison F et al. (2016) Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection. Immunity 45:861-876
Diekman, Brian O; Thakore, Pratiksha I; O'Connor, Shannon K et al. (2015) Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells. Tissue Eng Part A 21:1261-74
Daghestani, Hikmat N; Pieper, Carl F; Kraus, Virginia B (2015) Soluble macrophage biomarkers indicate inflammatory phenotypes in patients with knee osteoarthritis. Arthritis Rheumatol 67:956-65
Bokka, Kishore K; Jesudason, Edwin C; Lozoya, Oswaldo A et al. (2015) Morphogenetic Implications of Peristalsis-Driven Fluid Flow in the Embryonic Lung. PLoS One 10:e0132015

Showing the most recent 10 out of 41 publications