Abstract

The aim of the proposed Immunology Training Program is to provide academia, industry, and governmental research laboratories with highly creative and productive research immunologists who are broadly trained in immunology, well trained in their research specialty, and schooled in interrelated fields (e.g., pathogenesis of disease, cell biology, molecular biology, tumor biology). This goal is mandated by the intellectual desires and career aspirations of the program's participants and by the health needs of the nation. This goal will be achieved by having the predoctoral students follow a highly visible and defined Immunology Track (core curriculum) set in the established interdepartmental graduate training milieu of the University of Rochester School of Medicine and Dentistry. The essential core environment will be fostered by: a Division of Immunology faculty dedicated to excellence in teaching and research and committed to immunology training; active immunological research programs of trainees and their mentors; a structured lecture course in immunology and with an adjunct co-seminar; a series of advanced level seminar courses on cutting edge topics in immunology; a research-in-progress seminar series and a journal club; an active seminar series; and by a catalytic number of trainees. Breadth in training in fields related to immunology will be accomplished by students in the Immunology Track taking courses and/or seminars in pertinent areas of scientific inquiry that interface with immunology. Research training opportunities in a wide variety of immunological problems within the purview of B-cell biology (Bottaro, Insel, Phipps, Sanz, Young), T-cell biology (Barth, Cohen, Crispe, Fowell, Frelinger, Mosmann, Moynihan, Zheng), inflammation (Barth, Phipps, Segal), tumor immunity (Lord, Frelinger, Segal, Cohen), autoimmunity (Fowell, Segal), evolution of immunity (Cohen), and neural-immune system interactions (Moynihan, Cohen, Segal) will be offered to pre- and postdoctoral fellows by an experienced, talented, and highly interactive primary training faculty. Training support is requested for 10 predoctoral and 2 postdoctoral trainees in each of 5 years.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007285-19
Application #
6916584
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
1986-09-30
Project End
2007-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
19
Fiscal Year
2005
Total Cost
$399,078
Indirect Cost

  Institution

Name
University of Rochester
Department
Microbiology/Immun/Virology
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Boule, Lisbeth A; Burke, Catherine G; Jin, Guang-Bi et al. (2018) Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome. Sci Rep 8:1826
Cameron, Scott J; Mix, Doran S; Ture, Sara K et al. (2018) Hypoxia and Ischemia Promote a Maladaptive Platelet Phenotype. Arterioscler Thromb Vasc Biol 38:1594-1606
Richards, Katherine A; DiPiazza, Anthony T; Rattan, Ajitanuj et al. (2018) Diverse Epitope Specificity, Immunodominance Hierarchy, and Functional Avidity of Effector CD4 T Cells Established During Priming Is Maintained in Lung After Influenza A Virus Infection. Front Immunol 9:655
DiPiazza, Anthony; Laniewski, Nathan; Rattan, Ajitanuj et al. (2018) CD4 T Cell Epitope Specificity and Cytokine Potential Are Preserved as Cells Transition from the Lung Vasculature to Lung Tissue following Influenza Virus Infection. J Virol 92:
Simpson, Sydney; Fiches, Guillaume; Jean, Maxime J et al. (2018) Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi's Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells. Front Microbiol 9:788
DiPiazza, Anthony; Richards, Katherine; Poulton, Nicholas et al. (2017) Avian and Human Seasonal Influenza Hemagglutinin Proteins Elicit CD4 T Cell Responses That Are Comparable in Epitope Abundance and Diversity. Clin Vaccine Immunol 24:
Murphy, Patrick S; Wang, Jing; Bhagwat, Samir P et al. (2017) CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages. Cell Death Differ 24:559-570
DiPiazza, Anthony; Nogales, Aitor; Poulton, Nicholas et al. (2017) Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo. Sci Rep 7:10857
Hayashi, Tsuyoshi; Jean, Maxime; Huang, Huachao et al. (2017) Screening of an FDA-approved compound library identifies levosimendan as a novel anti-HIV-1 agent that inhibits viral transcription. Antiviral Res 146:76-85
Jean, Maxime J; Hayashi, Tsuyoshi; Huang, Huachao et al. (2017) Curaxin CBL0100 Blocks HIV-1 Replication and Reactivation through Inhibition of Viral Transcriptional Elongation. Front Microbiol 8:2007

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