application) This application requests renewal of a combined pre- and post-doctoral training program in Molecular and Cellular Immunobiology. Immunology at Stanford is interdepartmental in organization, with 31 faculty from 13 departments in the Schools of Medicine and of Humanities and Sciences, and multidisciplinary in nature. Pre-doctoral trainees are required to develop a strong background in basic biomedical sciences through coursework, and they receive extensive and broad- based research training through laboratory rotations and thesis research. Both pre-and post-doctoral trainees develop professional skills and perspectives through participation in program activities including the weekly Immunology Seminar Series, journal clubs, the annual Stanford Immunology Retreat, and the course in the Responsible Conduct of Research. Trainees are also encouraged to present their research at local and national conferences. Trainees have access to modern laboratories, many in new or newly-renovated buildings, and to state-of-the-art specialized research facilities, such as the FACS Facility, Protein and Nucleic Acid Facility, Electron Microscope and Cell Imaging Facilities, Molecular Modeling Facility, and transgenic mouse facilities. This application seeks support for 12 pre-doctoral trainees (the number currently funded), all of whom are students in the interdepartmental Ph.D. Program in Immunology. An increase in the number of post-doctoral slots from 12 to 14 is requested to reflect the increase in the number of preceptors, from 25 to 31 (there are actually 12 new preceptors; 6 faculty left the program due to retirement, move, or changed interests). The training programs are directed by the Program Director, Dr. Irving Weissman, with the assistance of Associate Directors Drs. Mark Davis, Director of the Pre-doctoral Program, and Eugene Butcher, Director of the Post- doctoral Program. They are assisted by the Executive Committee, which oversees preceptor selection and Program activities, policies, and finances, and by the Pre-doctoral and Post-doctoral Committees, which oversee admissions and program operation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007290-15
Application #
2886168
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
1985-09-01
Project End
2000-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
15
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Stanford University
Department
Pathology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Kronstad, Lisa M; Seiler, Christof; Vergara, Rosemary et al. (2018) Differential Induction of IFN-? and Modulation of CD112 and CD54 Expression Govern the Magnitude of NK Cell IFN-? Response to Influenza A Viruses. J Immunol 201:2117-2131
Blum, Lisa K; Cao, Richard R L; Sweatt, Andrew J et al. (2018) Circulating plasmablasts are elevated and produce pathogenic anti-endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension. Eur J Immunol 48:874-884
Pugh, Jason L; Nemat-Gorgani, Neda; Norman, Paul J et al. (2018) Human NK Cells Downregulate Zap70 and Syk in Response to Prolonged Activation or DNA Damage. J Immunol 200:1146-1158
Sockolosky, Jonathan T; Trotta, Eleonora; Parisi, Giulia et al. (2018) Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science 359:1037-1042
Sibener, Leah V; Fernandes, Ricardo A; Kolawole, Elizabeth M et al. (2018) Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell 174:672-687.e27
Casey, Stephanie C; Baylot, Virginie; Felsher, Dean W (2018) The MYC oncogene is a global regulator of the immune response. Blood 131:2007-2015
Ju, Chia-Hsin; Blum, Lisa K; Kongpachith, Sarah et al. (2018) Plasmablast antibody repertoires in elderly influenza vaccine responders exhibit restricted diversity but increased breadth of binding across influenza strains. Clin Immunol 193:70-79
Gee, Marvin H; Han, Arnold; Lofgren, Shane M et al. (2018) Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes. Cell 172:549-563.e16
Rosental, Benyamin; Kowarsky, Mark; Seita, Jun et al. (2018) Complex mammalian-like haematopoietic system found in a colonial chordate. Nature 564:425-429
Anchang, Benedict; Davis, Kara L; Fienberg, Harris G et al. (2018) DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity. Proc Natl Acad Sci U S A 115:E4294-E4303

Showing the most recent 10 out of 337 publications