We propose to improve the quality of the Immunology Training Program at the Geisel School of Medicine at Dartmouth (GSOM) that has been supported by the NIH T32 grant, ?Immunobiology of myeloid and lymphoid cells?, for the past twenty-five years. The overall goal of this application is to train the best graduate students and postdoctoral researchers to become ethical, productive, and well-informed independent investigators. The scientific focus of this training grant is the discovery and understanding of how the immune system and immune cells function in health and disease. The training proposed is multi-faceted, and includes design, strategy and interpretation of laboratory research, ethical and reproducible conduct of research, mentorship with career planning, and enhanced writing and presentation skills. Scientific training occurs in both animal and human systems. The program faculty's research interests span a wide range of immunologic areas that allows entering trainees a considerable breadth of conceptual and experimental choices of research topics. Research topics include, but are not limited to, antigen presentation and induction of immunity, immunity against viruses, tumor immunity and immunotherapy, inflammation, vaccines, mucosal immunity, regulation of immunity, and autoimmunity. A critical strength of the proposal is the high quality of the research programs of the sixteen faculty trainers, drawn from GSOM and the Thayer School of Engineering. GSOM has outstanding research facilities, especially with the addition of the Williams translational research building in 2015. The laboratories are fully equipped to support a full-range of state-of- the-art research in immunology, biochemistry, and molecular biology techniques. Dartmouth has AAALAC approved animal facilities. Dartmouth has founded a new School in Graduate and Advanced Studies that is designed specifically to foster the professional development and success of graduate students and postdocs. Training in immunology spans several graduate programs: Molecular and Cell Biology, the Program in Experimental and Molecular Medicine, and the Program in Quantitative Biomedical Sciences. Consistent with the needs of future scientists, Immunology training at Dartmouth involves a multi/interdisciplinary approach nurtured by a highly interactive environment. Students and postdoctoral fellows benefit from a vigorous faculty involvement and scientific exchanges characteristic of the Dartmouth tradition of close student-faculty interactions. In addition to classic scientific training, we offer professional development courses and workshops to help students, postdoctoral fellows, and faculty succeed in their careers. The Immunology Program has an outstanding track record of success, and we propose to build on this success to educate and promote the next generation of research scientists in immunology.

Public Health Relevance

This proposal is designed to expand and continue to improve the quality of the Immunology Training Program at The Geisel School of Medicine at Dartmouth. The primary goal of this program is to recruit highly motivated and talented postdoctoral fellows and graduate students and to provide them with first-rate training in immunology to prepare them for scientific research careers, including careers in academia as independent investigators. The scientific focus of this training grant is the discovery and understanding of how the immune system and immune cells function in health and disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007363-27
Application #
9722155
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Gondre-Lewis, Timothy A
Project Start
1990-09-30
Project End
2023-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
27
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Torres, Iviana M; Patankar, Yash R; Berwin, Brent (2018) Acidosis exacerbates in vivo IL-1-dependent inflammatory responses and neutrophil recruitment during pulmonary Pseudomonas aeruginosa infection. Am J Physiol Lung Cell Mol Physiol 314:L225-L235
Nowak, Elizabeth C; Lines, J Louise; Varn, Frederick S et al. (2017) Immunoregulatory functions of VISTA. Immunol Rev 276:66-79
Malik, Brian T; Byrne, Katelyn T; Vella, Jennifer L et al. (2017) Resident memory T cells in the skin mediate durable immunity to melanoma. Sci Immunol 2:
Godbersen, Claire; Coupet, Tiffany A; Huehls, Amelia M et al. (2017) NKG2D Ligand-Targeted Bispecific T-Cell Engagers Lead to Robust Antitumor Activity against Diverse Human Tumors. Mol Cancer Ther 16:1335-1346
Armstrong, David A; Nymon, Amanda B; Ringelberg, Carol S et al. (2017) Pulmonary microRNA profiling: implications in upper lobe predominant lung disease. Clin Epigenetics 9:56
O'Connor, Megan A; Rastad, Jessica L; Green, William R (2017) The Role of Myeloid-Derived Suppressor Cells in Viral Infection. Viral Immunol 30:82-97
Fox, Barbara A; Butler, Kiah L; Guevara, Rebekah B et al. (2017) Cancer therapy in a microbial bottle: Uncorking the novel biology of the protozoan Toxoplasma gondii. PLoS Pathog 13:e1006523
Jiang, Yike; Patel, Chaya D; Manivanh, Richard et al. (2017) Maternal Antiviral Immunoglobulin Accumulates in Neural Tissue of Neonates To Prevent HSV Neurological Disease. MBio 8:
Butler, Kiah L; Clancy-Thompson, Eleanor; Mullins, David W (2017) CXCR3+ monocytes/macrophages are required for establishment of pulmonary metastases. Sci Rep 7:45593
Torres, Iviana M; Demirdjian, Sally; Vargas, Jennifer et al. (2017) Acidosis increases the susceptibility of respiratory epithelial cells to Pseudomonas aeruginosa-induced cytotoxicity. Am J Physiol Lung Cell Mol Physiol 313:L126-L137

Showing the most recent 10 out of 146 publications