This application proposes a continuation of the current Interdisciplinary Research Training Program in AIDS at Duke. Over the last several years, the Duke University program in AIDS research has increased its specific research base to include 38 investigators representing nine academic departments with an aggregate of over 29,000 square feet of laboratory space and financial support of $18,000,000 from governmental, private and industry awards. Coordinated and administered by the adult Division of Infectious Diseases, the training program has filled all five of its allotted slots in the first four years. Seven of the eight individuals who have completed the program have or are expected to enter full-time academic positions that include research in HIV. The range of opportunities for trainees includes both basic and clinical science. The former is organized into four areas as follows: 1) HIV envelope targets for vaccines and therapeutics led by Dr. Barton Haynes, 2) cellular immunotherapy led by Dr. Kent Weinhold, 3) molecular biology and gene therapy led by Drs. Bryan Cullen and Eli Gilboa, and 4) the Central Immunology Laboratory for AIDS vaccine clinical trials. These basic science programs are further supported by core laboratories including (a) peptide synthesis, (b) flow cytometry, and (c) gene expression. These basic science programs interact closely with the adult and pediatric clinical components of the Duke CFAR that are actively engaged in the conduct of clinical trials of therapeutic and preventive products identified in the basic science programs and others.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007392-10
Application #
2886195
Study Section
Special Emphasis Panel (SRC (61))
Program Officer
Sager, Polly R
Project Start
1990-08-01
Project End
2000-04-30
Budget Start
1999-05-01
Budget End
2000-04-30
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Clement, Meredith E; Lin, Li; Navar, Ann Marie et al. (2018) Lower likelihood of cardiac procedures after acute coronary syndrome in patients with human immunodeficiency virus/acquired immunodeficiency syndrome. Medicine (Baltimore) 97:e9849
Mulawa, Marta I; Kajula, Lusajo J; Maman, Suzanne (2018) Peer network influence on intimate partner violence perpetration among urban Tanzanian men. Cult Health Sex 20:474-488
Skalski, Linda M; Towe, Sheri L; Sikkema, Kathleen J et al. (2018) Memory Impairment in HIV-Infected Individuals with Early and Late Initiation of Regular Marijuana Use. AIDS Behav 22:1596-1605
Mulawa, Marta I; Yamanis, Thespina J; Kajula, Lusajo J et al. (2018) Structural Network Position and Performance of Health Leaders Within an HIV Prevention Trial. AIDS Behav 22:3033-3043
Garrido, Carolina; Abad-Fernandez, Maria; Tuyishime, Marina et al. (2018) Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo. J Virol 92:
Mulawa, Marta I; Reyes, H Luz McNaughton; Foshee, Vangie A et al. (2018) Associations Between Peer Network Gender Norms and the Perpetration of Intimate Partner Violence Among Urban Tanzanian Men: a Multilevel Analysis. Prev Sci 19:427-436
Pacek, Lauren R; Joseph McClernon, F; Denlinger-Apte, Rachel L et al. (2018) Perceived nicotine content of reduced nicotine content cigarettes is a correlate of perceived health risks. Tob Control 27:420-426
Sikkema, Kathleen J; Mulawa, Marta I; Robertson, Corne et al. (2018) Improving AIDS Care After Trauma (ImpACT): Pilot Outcomes of a Coping intervention Among HIV-Infected Women with Sexual Trauma in South Africa. AIDS Behav 22:1039-1052
Bonsignori, Mattia; Scott, Eric; Wiehe, Kevin et al. (2018) Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier. Immunity 49:1162-1174.e8
Towe, Sheri L; Horton, Olivia E; Martin, Bianca et al. (2018) A Comparison of Motivations for Marijuana Use in HIV-Positive and HIV-Negative Adults. AIDS Behav 22:2807-2814

Showing the most recent 10 out of 133 publications