This proposal is a revised request for continued funding of an institutional combined pre- and postdoctoral NRSA Training Program in Immunology and Molecular pathogenesis at the Feinberg School of Medicine of Northwestern University which was funded from 1996-2006. The predoctoral training program will be run in conjunction with the Immunology and Molecular Pathogenesis graduate track, a component of the highly successful Integrated Graduate Program in the Life Sciences (IGP). The IGP will be the mechanism for recruitment of a pool of highly qualified graduate students from which predoctoral candidates will be selected. The training program is also supported by the Northwestern Interdepartmental Immunobiology Center. The training program will stress the interactive nature of immunology and molecular pathogenesis, two traditionally related disciplines. Successful research in immunology and molecular pathogenesis requires consultation and collaboration among colleagues. This program includes 23 highly productive researchers experienced in pre- and postdoctoral training who collectively hold >14 million dollars per year in research funding and who can impart both basic and clinical perspectives to a group of outstanding pre- and post-doctoral trainees. The result will be a more productive research environment, both for the pre- and postdoctoral students and for the many research projects funded by grants from the NIH and other federal and private agencies. The training grant also proposes to foster trainee interactions with scientists at other institutions through trainee travel to national meetings (to present and receive critiques on their research and to develop contacts with other scientists) and through visits of prominent scientists to the Feinberg School of Medicine as trainee-invited speakers. The training program also serves to focus the activities at the University aimed at educating students in the ethics of science and at recruiting women and minorities to graduate and post-graduate studies in immunology and molecular pathogenesis. The program requests maintaining the current four predoctoral and two postdoctoral slots. Predoctoral students will be appointed for a 2 year period at the end of the second year of graduate studies after they have completed their coursework and qualifying exams and have identified a research advisor, while postdoctoral candidates will be appointed at the outset of their training for a 1-2 year period while they apply for independent funding. Refunding of the ongoing program will give training in immunology and molecular pathogenesis at Northwestern the continuity required to maintain the momentum gained during the previous funding periods and will allow the continued supply of highly trained young investigators with primary interests in the basic mechanisms of host-parasite interactions and immune regulatory functions governing disease processes. ? ? ? ?

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Prograis, Lawrence J
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Northwestern University at Chicago
Schools of Medicine
United States
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Quillin, Sarah J; Hockenberry, Adam J; Jewett, Michael C et al. (2018) Neisseria gonorrhoeae Exposed to Sublethal Levels of Hydrogen Peroxide Mounts a Complex Transcriptional Response. mSystems 3:
DiGiuseppe, Stephen; Rollins, Madeline G; Bartom, Elizabeth T et al. (2018) ZNF598 Plays Distinct Roles in Interferon-Stimulated Gene Expression and Poxvirus Protein Synthesis. Cell Rep 23:1249-1258
White, Richard C; Gunderson, Felizza F; Tyson, Jessica Y et al. (2018) Type II Secretion-Dependent Aminopeptidase LapA and Acyltransferase PlaC Are Redundant for Nutrient Acquisition during Legionella pneumophila Intracellular Infection of Amoebas. MBio 9:
Woida, Patrick J; Satchell, Karla J F (2018) Coordinated delivery and function of bacterial MARTX toxin effectors. Mol Microbiol 107:133-141
Quillin, Sarah Jane; Seifert, H Steven (2018) Neisseria gonorrhoeae host adaptation and pathogenesis. Nat Rev Microbiol 16:226-240
Meade, Nathan; Furey, Colleen; Li, Hua et al. (2018) Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit. Cell 174:1143-1157.e17
Nas, Megan Y; Cianciotto, Nicholas P (2017) Stenotrophomonas maltophilia produces an EntC-dependent catecholate siderophore that is distinct from enterobactin. Microbiology 163:1590-1603
Delaney, Michael Keegan; Malikov, Viacheslav; Chai, Qingqing et al. (2017) Distinct functions of diaphanous-related formins regulate HIV-1 uncoating and transport. Proc Natl Acad Sci U S A 114:E6932-E6941
Möhl, Britta S; Chen, Jia; Park, Seo Jin et al. (2017) Epstein-Barr Virus Fusion with Epithelial Cells Triggered by gB Is Restricted by a gL Glycosylation Site. J Virol 91:
Pothoven, Kathryn L; Norton, James E; Suh, Lydia A et al. (2017) Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease. J Allergy Clin Immunol 139:1966-1978.e9

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