This is a competitive renewal application for years 11-16 of a training program supporting students pursuing doctoral studies in basic and translational immunology at The University of Iowa. A diversity of areas of immunology available to the students is a strength of the program. The average duration from matriculation to completion is 5 years. The ultimate goal of the Interdisciplinary Graduate Program in Immunology is to develop the capabilities of our students to become successful independent investigators in the variety of careers available in basic and applied immunology. The major focus of the training program is intensive laboratory research conducted under the guidance and mentorship of outstanding faculty immunologists. Complementary aspects of the program include coursework that stresses hypothesis generation and critical analysis skills, a rigorous research-oriented comprehensive examination, training in ethical issues facing biomedical scientists, and ample opportunities to gain proficiency in scientific writing and speaking. Students are selected without regard for any characteristics other than their potential as scientists, and are drawn from pools of applicants seeking the Ph.D. in Immunology, the M.D./Ph.D. combined degree, and initially undecided students who select an area of focus at the end of the first year of graduate study. Thirty faculty in the Program are divided into 4 categories. Experienced Mentor/Mentor faculty are active, productive researchers who have successfully trained Ph.D. students (EM) or have trained fellows, but not yet graduate students (M). New Mentors (NM) are junior faculty with appropriate training, and Resource Faculty (R) do not serve as dissertation advisors, but are valuable to the training program in teaching and committee service. How each of these categories of faculty contribute to the program and participate in graduate training is described in detail in the proposal. Information included herein documents faculty qualifications, student progress, administrative structure of the program, and the detailed training plan for our students. This grant is critical to support our continuing efforts in training pre-doctoral students from diverse backgrounds for independent careers as immunologists, and also to providing geographic diversity in graduate training in immunology. ? ?

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Iowa
Schools of Medicine
Iowa City
United States
Zip Code
Hornick, Emma E; Banoth, Balaji; Miller, Ann M et al. (2018) Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection. J Immunol 200:1188-1197
Freedman, Samantha N; Shahi, Shailesh K; Mangalam, Ashutosh K (2018) The ""Gut Feeling"": Breaking Down the Role of Gut Microbiome in Multiple Sclerosis. Neurotherapeutics 15:109-125
Gorman, Jacob V; Colgan, John D (2018) Acute stimulation generates Tim-3-expressing T helper type 1 CD4 T cells that persist in vivo and show enhanced effector function. Immunology 154:418-433
Carlin, Lindsey E; Hemann, Emily A; Zacharias, Zeb R et al. (2018) Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose. Front Immunol 9:781
Jensen, Isaac J; Sjaastad, Frances V; Griffith, Thomas S et al. (2018) Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity. J Immunol 200:1543-1553
Zacharias, Zeb R; Ross, Kathleen A; Hornick, Emma E et al. (2018) Polyanhydride Nanovaccine Induces Robust Pulmonary B and T Cell Immunity and Confers Protection Against Homologous and Heterologous Influenza A Virus Infections. Front Immunol 9:1953
Nada, Mohanad H; Wang, Hong; Workalemahu, Grefachew et al. (2017) Enhancing adoptive cancer immunotherapy with V?2V?2 T cells through pulse zoledronate stimulation. J Immunother Cancer 5:9
Vijay, Rahul; Fehr, Anthony R; Janowski, Ann M et al. (2017) Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling. Proc Natl Acad Sci U S A 114:E5444-E5453
Vacaflores, Aldo; Freedman, Samantha N; Chapman, Nicole M et al. (2017) Pretreatment of activated human CD8 T cells with IL-12 leads to enhanced TCR-induced signaling and cytokine production. Mol Immunol 81:1-15
Gullicksrud, Jodi A; Li, Fengyin; Xing, Shaojun et al. (2017) Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection. J Immunol 199:911-919

Showing the most recent 10 out of 81 publications