The intersection of genomics and infectious diseases has defined one of the most important leading edges in contemporary science and one of the most critical areas of advancement in medicine, and as a result, has provided a rich intellectual foundation for the training of postdoctoral scholars in infectious diseases. The objectives of the grant are to train M.D. and Ph.D. post-doctoral fellows in the application of genomics to infectious diseases, and to prepare them for successful, productive, independent careers that have a significant impact on the health-related research needs of the nation. We propose to prepare all trainees- irrespective of whether they intend to conduct their research at the bench or from the bedside, in fundamentals of both genomics and applied clinical investigation, with the goal of enhancing the translation of scientific discoveries into clinical practice. We request support for five postdoctoral fellows each year. Ph.D. candidates who have completed their thesis work and M.D. candidates who have completed their clinical training will be evaluated by the Program's Steering Committee and offered admission on the basis of exceptional academic record, faculty interviews, and interest in, and aptitude for research. Every effort will be made to attract minority candidates. The training program will be interdisciplinary, involving faculty from Applied Physics, Biology, Biochemistry, Bioengineering, Chemical Engineering, Chemistry, Emergency Medicine, Genetics, Health Research and Policy, Medicine, Microbiology & Immunology, Pathology, and Pediatrics. All fellows will train for at least two years. Each trainee will be encouraged to take courses in clinical research and in basic sciences related to genomics. Additionally, each trainee will complete a two- year interdisciplinary core curriculum in applied genomics of infectious diseases. Beginning in the first year, each fellow will embark on an in-depth research project supervised by one or more of the Program's faculty; in many cases, joint-mentoring will involve faculty from different disciplines. In this way, many research projects will be cross-disciplinary. Seminars by trainees and an annual research retreat will promote interactions between program participants. While support from the Training grant will be for one year, a minimum of two years of support is guaranteed for each trainee using funds from the faculty mentor; all fellows will be encouraged to seek independent support after the first year. The program intends to meet a recognized need for clinician-scientists in Infectious Diseases who are trained in functional and applied genomics ? a recognized strength at Stanford University School of Medicine. This training grant has been, and continues to be the primary source of postdoctoral research training support for clinician-scholars. Trainees are expected to transition to independent positions in academia or industry, or positions in public health leadership and apply their education in genomics to address pressing issues in infectious diseases.

Public Health Relevance

The objectives of the grant are to train M.D. and Ph.D. post-doctoral fellows in the application of genomics to infectious diseases, and to prepare them for successful, productive, independent careers that have a significant impact on the health-related research needs of the nation. The training program will exploit the world-class resources and leadership at the host institution in the field of genomics. Graduating trainees from this program will be unusually well-prepared to enhance the public health through the application of this powerful field of science.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
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Stanford University
Internal Medicine/Medicine
Schools of Medicine
United States
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Benamu, Esther; Yu, Alexander Tin-Han; Xie, Lijia et al. (2018) Scedosporium apiospermum infection of the urinary system with a review of treatment options and cases in the literature. Transpl Infect Dis 20:
Lou, Hongfei; Lu, Jingning; Choi, Eun Byul et al. (2017) Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction, and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP Pathway. J Immunol 198:2543-2555
Whitaker, Weston R; Shepherd, Elizabeth Stanley; Sonnenburg, Justin L (2017) Tunable Expression Tools Enable Single-Cell Strain Distinction in the Gut Microbiome. Cell 169:538-546.e12
Tan, Susanna K; Milligan, Stephen; Sahoo, Malaya K et al. (2017) Calibration of BK Virus Nucleic Acid Amplification Testing to the 1st WHO International Standard for BK Virus. J Clin Microbiol 55:923-930
Vendrame, Elena; Fukuyama, Julia; Strauss-Albee, Dara M et al. (2017) Mass Cytometry Analytical Approaches Reveal Cytokine-Induced Changes in Natural Killer Cells. Cytometry B Clin Cytom 92:57-67
Tan, Susanna K; Relman, David A; Pinsky, Benjamin A (2017) The Human Virome: Implications for Clinical Practice in Transplantation Medicine. J Clin Microbiol 55:2884-2893
Waldron, Paul Ravi; Belitskaya-Lévy, Ilana; Chary, Aarthi et al. (2016) Genetic Variation in the IL-6 and HLA-DQB1 Genes Is Associated with Spontaneous Clearance of Hepatitis C Virus Infection. J Immunol Res 2016:6530436
Andermann, Tessa M; Rezvani, Andrew; Bhatt, Ami S (2016) Microbiota Manipulation With Prebiotics and Probiotics in Patients Undergoing Stem Cell Transplantation. Curr Hematol Malig Rep 11:19-28
Schanz, Julie (2016) Helpful Tool or Oversimplification? Concept of the Monosomal Karyotype from the Clinical and Cytogenetic Point of View. Biol Blood Marrow Transplant 22:191-192
Andermann, Tessa M; Bhatt, Ami S (2016) Antibiotics in Hematopoietic Cell Transplantation: Adversaries or Allies? Biol Blood Marrow Transplant 22:972-974

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