The specific objectives of the training program are to train graduate students and postdoctoral fellows in the application of principles and theories of modern biotechnology to specific disease problems. The Pathobiology program provides a link between molecular approaches and public health. This is supported by the course requirements in our graduate program which include core courses in Pathobiology emphasizing disease concepts, and courses in epidemiology, immunology, and molecular biology. The multiple research collaborations melding our laboratory-based training with other Public Health Disciplines offer unique opportunities to conduct multidisciplinary studies on diseases in human populations. There are several aspects that distinguish our training program: 1) A focus on pathogens with relevance to global health; 2) An interdisciplinary approach to genetic or infectious contributors to chronic disease; 3) A relevance to maternal prevention and intervention; 4) An emphasis on emerging and re-emerging global health issues; 5) A focus on novel strategies for prevention and intervention; and 6) A focus on identification of biomarkers. The Pathobiology training program has 45 training faculty members. The predoctoral training program in Pathobiology was approved by the University of Washington Graduate School in 1990 and received Interdisciplinary Program Status in 2006. We have graduated 102 PhDs since 1990. Of these 102, 35 have received their PHD degree since 2009. Since 1990, our faculty has trained over 560 postdoctoral fellows. The proposed training program will train 3 predoctoral and 3 postdoctoral trainees per year. The combination of diverse research and classroom environments provide a strong integrated approach to enable trainees to prepare for and deal most effectively with the impact of disease on global Public Health.

Public Health Relevance

The specific objective our training program 'Diseases of Public Health Importance' is to provide interdisciplinary training in basic sciences related to the etiology, pathogenesis, prevention, and cure of globally important diseases. The ultimate goal is to provide our future basic scientists with the ability to combat infectious disease challenges to find solutions toward global health needs through innovative research.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Public Health & Prev Medicine
Schools of Medicine
United States
Zip Code
Vornhagen, Jay; Quach, Phoenicia; Santana-Ufret, VerĂ³nica et al. (2018) Human Cervical Mucus Plugs Exhibit Insufficiencies in Antimicrobial Activity Towards Group B Streptococcus. J Infect Dis 217:1626-1636
Adams Waldorf, Kristina M; Nelson, Branden R; Stencel-Baerenwald, Jennifer E et al. (2018) Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain. Nat Med 24:368-374
Gendrin, Claire; Vornhagen, Jay; Armistead, Blair et al. (2018) A Nonhemolytic Group B Streptococcus Strain Exhibits Hypervirulence. J Infect Dis 217:983-987
Cohen, Sara B; Gern, Benjamin H; Delahaye, Jared L et al. (2018) Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination. Cell Host Microbe 24:439-446.e4
Vornhagen, Jay; Armistead, Blair; Santana-Ufret, VerĂ³nica et al. (2018) Group B streptococcus exploits vaginal epithelial exfoliation for ascending infection. J Clin Invest 128:1985-1999
Glennon, Elizabeth K K; Dankwa, Selasi; Smith, Joseph D et al. (2018) Opportunities for Host-targeted Therapies for Malaria. Trends Parasitol 34:843-860
Mpina, Maxmillian; Maurice, Nicholas J; Yajima, Masanao et al. (2017) Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations. J Immunol 199:107-118
Moguche, Albanus O; Musvosvi, Munyaradzi; Penn-Nicholson, Adam et al. (2017) Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis. Cell Host Microbe 21:695-706.e5
Wargo, Andrew R; Scott, Robert J; Kerr, Benjamin et al. (2017) Replication and shedding kinetics of infectious hematopoietic necrosis virus in juvenile rainbow trout. Virus Res 227:200-211
Wood, Lianna Frances; Wood, Matthew P; Fisher, Bridget S et al. (2017) T Cell Activation in South African HIV-Exposed Infants Correlates with Ochratoxin A Exposure. Front Immunol 8:1857

Showing the most recent 10 out of 84 publications