The prevalence of allergic and immunological disorders has been steadily increasing in the pediatric population with more than 15% of children affected. However, the number of physicians both treating and investigating immunologic and allergic responses in children remains disproportionately small. Recent advances in our understanding of the immune system, along with the emergence of powerful yet complex research technologies in molecular biology, human genetics and immunobiology have created fertile ground for advancement of understanding of immunological mechanisms but also make it essential for trainees in the fields of allergy, immunology and rheumatology to undergo rigorous training in basic immunology in a cutting edge environment. Such training will prepare young physicians and Ph.D. scientists to advance our knowledge of these diseases through basic research, clinical research and the implementation of novel therapeutic strategies. Equally important, such training will prepare a cadre of physician scientists who will train the next generation of physician scientists. The proposed training program will seek the most talented and committed young pediatricians as well as Ph.D. scientists (all postdoctoral) committed to clinically applicable immunology research and will provide them with intensive training experience in research in an unparalleled environment. All training will be within the general discipline of Immunology, with a broad representation of immunology topics (allergy, tolerance, T cell function, B cell function, autoimmunity, immune regulation and immune deficiency) covered by a diverse and internationally-recognized faculty in the Harvard Medical School community. A three year training experience is proposed;physicians will receive a year one year of clinical training (not funded by this grant) prior to entering the program. The program will fund 9 trainees per year, each with M.D. , M.D., Ph.D. or Ph.D. credentials.

Public Health Relevance

Allergies and immune system diseases are becoming increasingly common, especially in children. Treatment options are limited so research to identify both the roots of allergy and possible treatments is critical. This Training Program seeks to recruit talented young pediatricians and Ph.D. scientists committed to translational research and to prepare them for careers as productive researchers in the area of pediatric immunology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI007512-26
Application #
8150208
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
1986-08-01
Project End
2016-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
26
Fiscal Year
2011
Total Cost
$530,652
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Lai, Peggy S; Kolde, Raivo; Franzosa, Eric A et al. (2018) The classroom microbiome and asthma morbidity in children attending 3 inner-city schools. J Allergy Clin Immunol 141:2311-2313
Lee, Pui Y; Huang, Yuelong; Zhou, Qing et al. (2018) Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2. J Allergy Clin Immunol 142:1363-1365.e8
Cohen, E M; D'Silva, K; Kreps, D et al. (2018) Arthritis and use of hydroxychloroquine associated with a decreased risk of macrophage activation syndrome among adult patients hospitalized with systemic lupus erythematosus. Lupus 27:1065-1071
Maeda, Kayaho; Otomo, Kotaro; Yoshida, Nobuya et al. (2018) CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease. J Clin Invest 128:3445-3459
Cohen, Ezra M; Dossett, Michelle L; Mehta, Darshan H et al. (2018) Factors associated with insomnia and complementary medicine use in children: results of a national survey. Sleep Med 44:82-88
Stranks, Amanda J; Minnicozzi, Samantha C; Miller, Samuel J et al. (2018) Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies. Ann Allergy Asthma Immunol :
Burton, Oliver T; Tamayo, Jaciel M; Stranks, Amanda J et al. (2018) Allergen-specific IgG antibody signaling through Fc?RIIb promotes food tolerance. J Allergy Clin Immunol 141:189-201.e3
Abbott, Jordan K; Huoh, Yu-San; Reynolds, Paul R et al. (2018) Dominant-negative loss of function arises from a second, more frequent variant within the SAND domain of autoimmune regulator (AIRE). J Autoimmun 88:114-120
Burton, O T; Medina Tamayo, J; Stranks, A J et al. (2018) IgE promotes type 2 innate lymphoid cells in murine food allergy. Clin Exp Allergy 48:288-296
Hu, Yeguang; Yoshida, Toshimi; Georgopoulos, Katia (2017) Transcriptional circuits in B cell transformation. Curr Opin Hematol 24:345-352

Showing the most recent 10 out of 99 publications