Viruses cause a diverse group of human illnesses. Viruses are also useful for expression of foreign genes which are particularly useful as vectors for the treatment of human genetic diseases and in cancer therapy. The development of a pool of scientists trained in virology is crucial to adequately deal with future public health problems. These include the areas of biodefense and emerging viruses. This training grant is intended to help meet this need. Ten participating faculty at The University of Iowa with interests in viral immunology, molecular virology, viral pathogenesis, and gene therapy using virus vectors are committed to training predoctoral students. Predoctoral trainees in virology from the Department of Microbiology and the Interdisciplinary Ph.D. programs in Genetics, Immunology and Molecular Biology will be selected for support based on their undergraduate and graduate academic records, their GRE scores, and their research potential. The trainees will participate in a training plan including research, coursework, seminars, journal clubs, and retreats in conjunction with the Helen C. Levitt Center for Viral Pathogenesis and Disease. The program goals are to 1) encourage further collaborations between the participating faculty members; 2) foster discussions between scientists and trainees with expertise in different areas of virology and 3) monitor the progress of trainees so that learning and productivity will be maximized. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007533-07
Application #
6937660
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
1998-09-01
Project End
2009-08-31
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
7
Fiscal Year
2005
Total Cost
$100,349
Indirect Cost
Name
University of Iowa
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Brouillette, Rachel B; Phillips, Elisabeth K; Patel, Radhika et al. (2018) TIM-1 Mediates Dystroglycan-Independent Entry of Lassa Virus. J Virol 92:
Balasubramaniam, Muthukumar; Zhou, Jing; Addai, Amma et al. (2018) PF74 Inhibits HIV-1 Integration by Altering The Composition of the Preintegration Complex. J Virol :
Welch, Jennifer L; Kaddour, Hussein; Schlievert, Patrick M et al. (2018) Semen exosomes promote transcriptional silencing of HIV-1 by disrupting NF-kB/Sp1/Tat circuitry. J Virol :
Grunewald, Matthew E; Fehr, Anthony R; Athmer, Jeremiah et al. (2018) The coronavirus nucleocapsid protein is ADP-ribosylated. Virology 517:62-68
DeLeon, Orlando; Hodis, Hagit; O'Malley, Yunxia et al. (2017) Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model. PLoS Biol 15:e2001549
Athmer, Jeremiah; Fehr, Anthony R; Grunewald, Matthew et al. (2017) In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins. MBio 8:
Bangalore-Prakash, Pradeep; Stunz, Laura L; Mambetsariev, Nurbek et al. (2017) The oncogenic membrane protein LMP1 sequesters TRAF3 in B-cell lymphoma cells to produce functional TRAF3 deficiency. Blood Adv 1:2712-2723
Das, Anshuman; Hirai-Yuki, Asuka; González-López, Olga et al. (2017) TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions. MBio 8:
Johnson, Jacklyn; Zhai, Yinjie; Salimi, Hamid et al. (2017) Induction of a Tier-1-Like Phenotype in Diverse Tier-2 Isolates by Agents That Guide HIV-1 Env to Perturbation-Sensitive, Nonnative States. J Virol 91:
Brouillette, Rachel B; Maury, Wendy (2017) Production of Filovirus Glycoprotein-Pseudotyped Vesicular Stomatitis Virus for Study of Filovirus Entry Mechanisms. Methods Mol Biol 1628:53-63

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