Support is requested for a continuation of a training program in emerging and reemerging infectious diseases that would support 7 postdoctoral trainees each year and prepare them for clinical, epidemiologic, applied or basic science careers in the field. Training is provided by 20 Program Faculty and 19 Associate Program Faculty, encompassing multidisciplinary approaches and the resources of several departments and centers, including Internal Medicine, Microbiology and Immunology, Pediatrics, Pathology and Preventive Medicine and Community Health, as well as the WHO Collaborating Center for Tropical Diseases (CTD), the Sealy Center for Vaccine Development, the Center for Biodefense and the Sealy Center for Structural Biology. UTMB also hosts the World Reference Center for Arboviruses and an Emerging Viral Diseases Unit that are supported by NIAID, and will complete construction of a biosafety level-4 research facility in 2003. The University has made a major commitment to research and training in the field by recruitment of senior, established faculty to facilitate research and training in the field. Very few medical schools in the ? United Stated can claim to have a faculty as large, as diverse, but collaborative in multidisciplinary studies, and of such excellence in the area of emerging infectious diseases. ? ? The program offers training in two general tracts: (1) basic investigations; and (2) clinical investigation. In the second tract, the trainee is encouraged to obtain an M.P.H. degree through the Department of Preventive Medicine and Community Health. At least three of the positions are designated for a Biodefense Training tract that addresses the CDC/NIAID Category A-to-C pathogens that are considered potential bioterrorist threats. The major objective of the training program is to foster development of basic or clinical research skills along with a collaborative approach to enable trainees to become independent investigators in the field of emerging and reemerging infectious diseases, applying multidisciplinary approaches to such important health threats. Research is conducted in all of the relevant pathogen-related disciplines, in pathogenetic mechanisms, and in vector biology. A strong feature of the proposed training program is the extensive availability of international field research experience. Training is thus available from state-of-the-art laboratories at UTMB to the most effective current techniques for research in the field under the supervision of UTMB faculty members. The trainees will be oriented thoroughly regarding contemporary problems in the relevant disciplines and wilt be provided with outstanding research opportunities. Most importantly, they will be prepared to embark on careers characterized by continual self-improvement and by utilization of future opportunities for collaboration and cross-disciplinary problem solving. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI007536-06
Application #
6658880
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Garges, Susan
Project Start
1998-08-01
Project End
2008-07-31
Budget Start
2003-08-01
Budget End
2004-07-31
Support Year
6
Fiscal Year
2003
Total Cost
$374,540
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Milligan, Gregg N; Sarathy, Vanessa V; White, Mellodee M et al. (2017) A lethal model of disseminated dengue virus type 1 infection in AG129 mice. J Gen Virol 98:2507-2519
Nishiyama, Shoko; Slack, Olga A L; Lokugamage, Nandadeva et al. (2016) Attenuation of pathogenic Rift Valley fever virus strain through the chimeric S-segment encoding sandfly fever phlebovirus NSs or a dominant-negative PKR. Virulence 7:871-881
Phoenix, Inaia; Nishiyama, Shoko; Lokugamage, Nandadeva et al. (2016) N-Glycans on the Rift Valley Fever Virus Envelope Glycoproteins Gn and Gc Redundantly Support Viral Infection via DC-SIGN. Viruses 8:
Vittor, Amy Y; Armien, Blas; Gonzalez, Publio et al. (2016) Epidemiology of Emergent Madariaga Encephalitis in a Region with Endemic Venezuelan Equine Encephalitis: Initial Host Studies and Human Cross-Sectional Study in Darien, Panama. PLoS Negl Trop Dis 10:e0004554
Opata, Michael M; Carpio, Victor H; Ibitokou, Samad A et al. (2015) Early effector cells survive the contraction phase in malaria infection and generate both central and effector memory T cells. J Immunol 194:5346-54
Whiteman, Melissa C; Popov, Vsevolod; Sherman, Michael B et al. (2015) Attenuated West Nile virus mutant NS1130-132QQA/175A/207A exhibits virus-induced ultrastructural changes and accumulation of protein in the endoplasmic reticulum. J Virol 89:1474-8
Sarathy, Vanessa V; White, Mellodee; Li, Li et al. (2015) A lethal murine infection model for dengue virus 3 in AG129 mice deficient in type I and II interferon receptors leads to systemic disease. J Virol 89:1254-66
Santiago, Felix W; Halsey, Eric S; Siles, Crystyan et al. (2015) Long-Term Arthralgia after Mayaro Virus Infection Correlates with Sustained Pro-inflammatory Cytokine Response. PLoS Negl Trop Dis 9:e0004104
Sarathy, Vanessa V; Infante, Ernesto; Li, Li et al. (2015) Characterization of lethal dengue virus type 4 (DENV-4) TVP-376 infection in mice lacking both IFN-?/? and IFN-? receptors (AG129) and comparison with the DENV-2 AG129 mouse model. J Gen Virol 96:3035-48
Ikegami, Tetsuro; Hill, Terence E; Smith, Jennifer K et al. (2015) Rift Valley Fever Virus MP-12 Vaccine Is Fully Attenuated by a Combination of Partial Attenuations in the S, M, and L Segments. J Virol 89:7262-76

Showing the most recent 10 out of 96 publications