The Mechanism of Virus-Host Interactions Training Grant is a multidisciplinary training program designed to train and educate pre-doctoral and post-doctoral trainees in the broad discipline of Virology. This proposal requests continued support for the Virology training program. The faculty is derived from two research institutions, the Mount Sinai School of Medicine (MSSM) and the NYU School of Medicine (NYUSM). The research training emphasis is directed toward teaching pre-doctoral and post-doctoral trainees the theory and experimental approaches required for independent scientific investigations. Students learn the molecular mechanisms involved in virus replication and host responses to viral infections. Research training areas also include novel approaches for antiviral strategies and vaccine development against medically relevant viruses. Our trainees are highly successful in attaining independent research positions, peer-reviewed publications, and extramural research funding. Accordingly, six pre-doctoral and six post-doctoral positions are requested.
The specific aim of the program is to recruit and provide rigorous training to high caliber students and fellows. The continued support of this program will aid trainees in all phases of their development including understanding scientific method, interpretation of results, presentation of data and conclusions, research ethics, and career guidance. By combining the strengths of an outstanding group of virologists, we have created a world-class virology training program. This program is built upon existing collaborations, including research grants, and joint publications between faculty members at MSSM and NYUSM. Accordingly, our collaborative training effort has """"""""added value"""""""" over single institution or individual based initiatives. The program faculty consists of twenty-eight outstanding virologists who use a diverse array of experimental strategies to study the molecular, cellular, biochemical and immunological interactions of viruses with their hosts.

Public Health Relevance

The Mechanism of Virus-Host Interactions Training Grant is vital to the development of the next generation of virologists. These trainees will be leaders in the field of Virology developing strategies to prevent and limit virus pathogenesis.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Program Officer
Robbins, Christiane M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Icahn School of Medicine at Mount Sinai
Schools of Medicine
New York
United States
Zip Code
Vink, Elizabeth I; Lee, Sora; Smiley, James R et al. (2018) Remodeling mTORC1 Responsiveness to Amino Acids by the Herpes Simplex Virus UL46 and Us3 Gene Products Supports Replication during Nutrient Insufficiency. J Virol 92:
Chacko, Kieran I; Sullivan, Mitchell J; Beckford, Colleen et al. (2018) Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia. Antimicrob Agents Chemother 62:
Taft, Justin D; Colonnetta, Megan M; Schafer, Rachel E et al. (2018) Dioxin Exposure Alters Molecular and Morphological Responses to Thyroid Hormone in Xenopus laevis Cultured Cells and Prometamorphic Tadpoles. Toxicol Sci 161:196-206
Sánchez-Aparicio, Maria T; Feinman, Leighland J; García-Sastre, Adolfo et al. (2018) Paramyxovirus V Proteins Interact with the RIG-I/TRIM25 Regulatory Complex and Inhibit RIG-I Signaling. J Virol 92:
Duehr, James; Lee, Silviana; Singh, Gursewak et al. (2018) Tick-Borne Encephalitis Virus Vaccine-Induced Human Antibodies Mediate Negligible Enhancement of Zika Virus Infection InVitro and in a Mouse Model. mSphere 3:
Aguado, Lauren C; Jordan, Tristan X; Hsieh, Emily et al. (2018) Homologous recombination is an intrinsic defense against antiviral RNA interference. Proc Natl Acad Sci U S A 115:E9211-E9219
Altman, Deena R; Sullivan, Mitchell J; Chacko, Kieran I et al. (2018) Genome Plasticity of agr-Defective Staphylococcus aureus during Clinical Infection. Infect Immun 86:
Bardina, Susana V; Bunduc, Paul; Tripathi, Shashank et al. (2017) Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Science 356:175-180
Duehr, James; Wohlbold, Teddy John; Oestereich, Lisa et al. (2017) Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model. J Virol 91:
Mitchell, Jonathan K; Midkiff, Bentley R; Israelow, Benjamin et al. (2017) Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R. MBio 8:

Showing the most recent 10 out of 137 publications