The overall goal of the proposed predoctoral training program is to contribute highly creative, productive and well trained HIV/AIDS researchers to meet national health and research priorities. This goal will be achieved by having a cadre of predoctoral students train in the well-established interdepartmental graduate training milieu of the University of Rochester School of Medicine and Dentistry (URMSD), under the supervision of experienced and caring mentors. This highly interactive core environment will be fostered by: a faculty dedicated to excellence in teaching and research and committed to training in HIV/AIDS research; outstanding HIV/AIDS research programs of the program faculty; lecture courses and structured seminars in various aspects of HIV/AIDS research; journal clubs; well-designed enrichment activities and workshops; and a catalytic number of trainees. Research opportunities in a wide variety of relevant problems within the purview of HIV/AIDS research will be offered to trainees by experienced mentors with strong extramural funding and an established history of collaboration. Specific objectives of the program are as follows: 1. To develop an interactive, productive and exciting interdisciplinary environment in which predoctoral trainees obtain an outstanding education in the area of HIV/AIDS research. This will be achieved by integrating faculty from several different departments and disciplines. 2. To provide an enriched training and learning environment for students, with skills workshops, structured seminar programs and journal clubs, distinguished extramural speakers, career development activities, enhanced training in the responsible conduct of research, and opportunities for training in mentoring. Students will also be trained to evaluate and write both manuscripts and grant applications. 3. To foster communication among trainees and faculty through the programs outlined above. This will exploit the intimate environment provided at the URSMD, where all the participating faculty and trainees work together in the same physical space, under a single roof. 4. To support training efforts in three major emphasis areas: (i) viral replication and reverse transcription, (ii) viral immunology and vaccine biology, and (iii) viral pathogenesis, with special emphasis on neuroAIDS and host factors that control virus replication. ? ? ? ?

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Sharma, Opendra K
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Rochester
Schools of Dentistry
United States
Zip Code
Miller-Rhodes, Patrick (2018) CX3CR1 Does Not Universally Mediate Microglia-Neuron Crosstalk during Synaptic Plasticity. J Neurosci 38:4457-4459
Brewer, Matthew G; DiPiazza, Anthony; Acklin, Joshua et al. (2017) Nanoparticles decorated with viral antigens are more immunogenic at low surface density. Vaccine 35:774-781
Singh, Meera V; Weber, Emily A; Singh, Vir B et al. (2017) Preventive and therapeutic challenges in combating Zika virus infection: are we getting any closer? J Neurovirol 23:347-357
Hilimire, Thomas A; Chamberlain, Jeffrey M; Anokhina, Viktoriya et al. (2017) HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells. ACS Chem Biol 12:1674-1682
Polevoda, Bogdan; McDougall, William M; Bennett, Ryan P et al. (2016) Structural and functional assessment of APOBEC3G macromolecular complexes. Methods 107:10-22
McAnany, John D; Reichert, John P; Miller, Benjamin L (2016) Probing the geometric constraints of RNA binding via dynamic covalent chemistry. Bioorg Med Chem 24:3940-3946
Hilimire, Thomas A; Bennett, Ryan P; Stewart, Ryan A et al. (2016) N-Methylation as a Strategy for Enhancing the Affinity and Selectivity of RNA-binding Peptides: Application to the HIV-1 Frameshift-Stimulating RNA. ACS Chem Biol 11:88-94
Jones, Letitia D; Jackson, Joseph W; Maggirwar, Sanjay B (2016) Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction. PLoS One 11:e0151702
Puccini, Jenna M; Marker, Daniel F; Fitzgerald, Tim et al. (2015) Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders. J Neurosci 35:5271-83
Lifson, Mark A; Carter, Jared A; Miller, Benjamin L (2015) Functionalized Polymer Microgel Particles Enable Customizable Production of Label-Free Sensor Arrays. Anal Chem 87:7887-93

Showing the most recent 10 out of 66 publications