This proposal is a new training initiative for pre-doctoral training in Tropical Infectious Diseases and requests funding for five trainees for five years. The Principal Investigator of the program is Professor Dyann Wirth and the program will be in the Department of Immunology and Infectious Diseases at the Harvard School of Public Health. The Harvard School of Public Health has recently made a new and expanded commitment to infectious diseases research through the creation of a new department called Immunology and Infectious Diseases (IID). The formation of this department was based on the recognition of the importance of infectious diseases in the overall global burden of disease, disproportionately affecting peoples living in developing countries in the tropical regions of the world. According to the World Health Organization, over one third of the deaths in the world in 1999 were due to infectious diseases and this proportion is likely to increase with spreading HIV/AIDS in many populous developing countries. Thus, there is an increasing need for research and training in infectious diseases and this training program addresses this need with an emphasis on developing country infectious diseases, including malaria, HIV and tuberculosis. The proposed training program provides for training of predoctoral students in tropical infectious diseases, including training in core knowledge areas of immunology, molecular biology, cell biology, biostatistics, biochemistry, genetics and genomics. Students, in addition, will receive advanced training focusing on specific infectious agents and the applications of modern approaches to vaccine and drug development for these important diseases. Much of the ongoing basic research in the Department of Immunology and Infectious Diseases addresses important areas of molecular pathogenesis, examining both host-pathogen and pathogen-vector interfaces. Trainees in this program will be exposed to integrated approaches that consider the host-pathogen relationship at the molecular and cellular levels, incorporating biochemistry and genomics, to generate a more broad perspective on disease pathogenesis and strategies for intervention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI049928-03
Application #
6632471
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2001-07-01
Project End
2006-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
3
Fiscal Year
2003
Total Cost
$178,845
Indirect Cost
Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Public Health
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Ross, Leila Saxby; Lafuente-Monasterio, Maria José; Sakata-Kato, Tomoyo et al. (2018) Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum. ACS Infect Dis 4:508-515
Hicks, Nathan D; Yang, Jian; Zhang, Xiaobing et al. (2018) Clinically prevalent mutations in Mycobacterium tuberculosis alter propionate metabolism and mediate multidrug tolerance. Nat Microbiol 3:1032-1042
Sakatos, Alexandra; Babunovic, Gregory H; Chase, Michael R et al. (2018) Posttranslational modification of a histone-like protein regulates phenotypic resistance to isoniazid in mycobacteria. Sci Adv 4:eaao1478
Ma, Kevin C; Unemo, Magnus; Jeverica, Samo et al. (2017) Genomic Characterization of Urethritis-Associated Neisseria meningitidis Shows that a Wide Range of N. meningitidis Strains Can Cause Urethritis. J Clin Microbiol 55:3374-3383
Herrera, Bobby Brooke; Chang, Charlotte A; Hamel, Donald J et al. (2017) Continued Transmission of Zika Virus in Humans in West Africa, 1992-2016. J Infect Dis 215:1546-1550
Martin, Constance J; Cadena, Anthony M; Leung, Vivian W et al. (2017) Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis. MBio 8:
Kurthkoti, Krishna; Amin, Hamel; Marakalala, Mohlopheni J et al. (2017) The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Granulomas. MBio 8:
Wong, Wesley; Griggs, Allison D; Daniels, Rachel F et al. (2017) Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal. Genome Med 9:5
Shell, Scarlet S; Wang, Jing; Lapierre, Pascal et al. (2015) Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape. PLoS Genet 11:e1005641
Volohonsky, Gloria; Terenzi, Olivier; Soichot, Julien et al. (2015) Tools for Anopheles gambiae Transgenesis. G3 (Bethesda) 5:1151-63

Showing the most recent 10 out of 17 publications