This proposal is a renewal for the training initiative for pre-doctoral training in Tropical Infectious Diseases and requests funding for five trainees for five years. The Principal Investigator is Professor Dyann Wirth, Chair of the Department of Immunology and Infectious Diseases. The training program will be centered at the Department of Immunology and Infectious Diseases at the Harvard School of Public Health (HSPH). According to the World Health Organization, over one third of the deaths in the world in 2005 were due to infectious diseases and this proportion is likely to increase with the spread of HIV/AIDS in developing countries. Thus, there is an increasing need for research and training in infectious diseases. The department has eighteen faculty members who are focused on developing country infectious diseases, specifically on malaria, HIV and tuberculosis. The renewal training program provides for training of predoctoral students in tropical infectious diseases, including training in core knowledge areas of immunology, molecular biology, cell biology, biostatistics, biochemistry, genetics and genomics. Students, in addition, will receive advanced training focusing on specific infectious agents and the applications of modern approaches to vaccine and drug development for these important diseases. Much of the ongoing basic research in the Department of Immunology and Infectious Diseases addresses important areas of molecular pathogenesis, in particular the host-pathogen interfaces. Trainees in this program will be exposed to integrated approaches that consider the host-pathogen relationship at the molecular and cellular levels, incorporating biochemistry and genomics, to generate a more broad perspective on disease pathogenesis and strategies for intervention.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases B Subcommittee (MID)
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Mcsweegan, Edward
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Harvard University
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Ross, Leila Saxby; Lafuente-Monasterio, Maria José; Sakata-Kato, Tomoyo et al. (2018) Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum. ACS Infect Dis 4:508-515
Hicks, Nathan D; Yang, Jian; Zhang, Xiaobing et al. (2018) Clinically prevalent mutations in Mycobacterium tuberculosis alter propionate metabolism and mediate multidrug tolerance. Nat Microbiol 3:1032-1042
Sakatos, Alexandra; Babunovic, Gregory H; Chase, Michael R et al. (2018) Posttranslational modification of a histone-like protein regulates phenotypic resistance to isoniazid in mycobacteria. Sci Adv 4:eaao1478
Ma, Kevin C; Unemo, Magnus; Jeverica, Samo et al. (2017) Genomic Characterization of Urethritis-Associated Neisseria meningitidis Shows that a Wide Range of N. meningitidis Strains Can Cause Urethritis. J Clin Microbiol 55:3374-3383
Herrera, Bobby Brooke; Chang, Charlotte A; Hamel, Donald J et al. (2017) Continued Transmission of Zika Virus in Humans in West Africa, 1992-2016. J Infect Dis 215:1546-1550
Martin, Constance J; Cadena, Anthony M; Leung, Vivian W et al. (2017) Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis. MBio 8:
Kurthkoti, Krishna; Amin, Hamel; Marakalala, Mohlopheni J et al. (2017) The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Granulomas. MBio 8:
Wong, Wesley; Griggs, Allison D; Daniels, Rachel F et al. (2017) Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal. Genome Med 9:5
Shell, Scarlet S; Wang, Jing; Lapierre, Pascal et al. (2015) Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape. PLoS Genet 11:e1005641
Volohonsky, Gloria; Terenzi, Olivier; Soichot, Julien et al. (2015) Tools for Anopheles gambiae Transgenesis. G3 (Bethesda) 5:1151-63

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