Our community of investigators seeks renewed support for a pre- and post-doctoral training program that addresses the role of microbes in health and disease at the University of Wisconsin-Madison. Microbiology is fundamentally important to human health due to the prevalence and consequences of infectious diseases. Its significance has been elevated by bioterrorism and discoveries of the unforeseen roles for microbes in certain human maladies and in promoting normal human physiology and health. The proposed Microbes in Health and Disease (MHD) training program represents the natural and synergistic synthesis of the broad disciplines microbial pathogenesis, beneficial microbiology, and host responses. MHD will have its physical and intellectual home in a state-of-the-art new Microbial Sciences Building where basic and clinical scientists interact and collaborate, providing a strong sense of place, cohesion and identity to the Training Program. Our pre-doctoral trainees are drawn chiefly from the Microbiology Doctoral Training Program (MDTP), a highly ranked graduate program. Our post-doctoral fellows are drawn chiefly from a strong pool of PhD and Infectious Disease MD fellows, the latter from a program with a long history of placing fellows into academic medicine. MHD trainees and faculty trainers hold program-wide bi-weekly meetings together, host invited speakers, and have a website and list serve. Medical Microbiology and Immunology, Bacteriology, Internal Medicine, and Pediatrics are core departments of MHD and MDTP activities, and offer required didactic, journal club and seminar courses to our trainees. Instruction is provided in host-microbe interactions, microbial pathogenesis, immunology, infectious disease, translational medicine, and the responsible conduct of research. Our 31 faculty trainers span 9 departments in 4 colleges and actively collaborate with each other in both research and teaching. All faculty trainers are productive scientists with proven NIH or equivalent funding records and strong records of graduate training. Most are tenured (20 full, 7 associate professors) and 4 promising junior faculty trainers will be mentored by senior training faculty. The training program faculty are dedicated to recruiting outstanding students and fellows, including focused efforts for minority candidates, and are committed to pre- and post-doctoral mentoring and didactic and research training. To support this commitment, and the NIH- stated need to train scientists in the area of microbes in health and disease, support is requested for 8 trainees annually: 5 predoctoral trainees, and 3 postdoctoral trainees, including two MD and one PhD fellows. Each trainee is mentored by a committee consisting of a thesis advisor or mentor and 4 other faculty, and all trainees are also co-mentored by virtue of joint trainer service on these committees. The program and its trainers are highly regarded in the scientific community, and fill a unique niche on campus and a critical national need. The success of the program in the past cycle is evidenced by 86 collective publications among the 15 trainees, and their progress into competitive postdoctoral positions or academic, industry or government research careers.
We propose the continuation of our pre-doctoral and post-doctoral training program on research in Microbiology and Infectious Diseases. The program, which is entitled Microbes in Health and Disease, focuses on training basic and clinical scientists in understanding the beneficial and harmful roles of microbes related to human health. The program has its intellectual and physical hub in an extraordinary new building devoted to microbial sciences that is located in the heart of the University of Wisconsin-Madison campus, where Microbiology training programs have been ranked among the best nationally. The training program offers a natural and synergistic synthesis of the contemporary fields microbial pathogenesis and host response together with symbiosis (beneficial microbiology). A cadre of outstanding faculty trainers across microbiology will offer trainees exposure to cutting edge topics and research in classrooms and laboratories, ensuring excellent doctoral or postdoctoral research training, and preparing them for successful and rewarding careers as leaders in Science.
|Murfin, Kristen E; Ginete, Daren R; Bashey, Farrah et al. (2018) Symbiont-mediated competition: Xenorhabdus bovienii confer an advantage to their nematode host Steinernema affine by killing competitor Steinernema feltiae. Environ Microbiol :|
|Bratburd, Jennifer R; Keller, Caitlin; Vivas, Eugenio et al. (2018) Gut Microbial and Metabolic Responses to Salmonella enterica Serovar Typhimurium and Candida albicans. MBio 9:|
|Baker, Steven F; Ledwith, Mitchell P; Mehle, Andrew (2018) Differential Splicing of ANP32A in Birds Alters Its Ability to Stimulate RNA Synthesis by Restricted Influenza Polymerase. Cell Rep 24:2581-2588.e4|
|Kujoth, Gregory C; Sullivan, Thomas D; Merkhofer, Richard et al. (2018) CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis. MBio 9:|
|Hernández-Santos, Nydiaris; Wiesner, Darin L; Fites, J Scott et al. (2018) Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection. Cell Host Microbe 23:511-522.e5|
|Neumann, Anthony P; Suen, Garret (2018) The Phylogenomic Diversity of Herbivore-Associated Fibrobacter spp. Is Correlated to Lignocellulose-Degrading Potential. mSphere 3:|
|Lind, Abigail L; Lim, Fang Yun; Soukup, Alexandra A et al. (2018) An LaeA- and BrlA-Dependent Cellular Network Governs Tissue-Specific Secondary Metabolism in the Human Pathogen Aspergillus fumigatus. mSphere 3:|
|Nanjappa, Som G; Mudalagiriyappa, Srinivasu; Fites, J Scott et al. (2018) CBLB Constrains Inactivated Vaccine-Induced CD8+ T Cell Responses and Immunity against Lethal Fungal Pneumonia. J Immunol 201:1717-1726|
|Contreras, Amanda; Beems, Megan V; Tatar, Andrew J et al. (2018) Co-transfer of tumor-specific effector and memory CD8+ T cells enhances the efficacy of adoptive melanoma immunotherapy in a mouse model. J Immunother Cancer 6:41|
|Mohr, Emma L; Block, Lindsey N; Newman, Christina M et al. (2018) Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection. PLoS One 13:e0190617|
Showing the most recent 10 out of 102 publications